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公开(公告)号：US11191742B2
公开(公告)日：2021-12-07
申请号：US15758405
申请日：2016-09-09
申请人： ALZHEON, INC.
发明人： Susan Abushakra , Aidan Power , Martin Tolar , John Hey , Jeremy Yu , Petr Kocis
IPC分类号： A61K31/185 , A61P25/28
摘要： Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.
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公开(公告)号：US20220087967A1
公开(公告)日：2022-03-24
申请号：US17264478
申请日：2019-07-30
申请人： Alzheon, Inc.
发明人： Petr Kocis , John Hey , Martin Tolar
IPC分类号： A61K31/221 , A61P25/28 , A61K31/22 , A61K31/185
摘要： Provided herein is the use of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, for treating a disease characterized by amyloid and amyloid-like aggregates, e.g., Alzheimer's disease.
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公开(公告)号：US20200347012A1
公开(公告)日：2020-11-05
申请号：US16807747
申请日：2020-03-03
申请人： Alzheon, Inc.
发明人： Petr Kocis , Martin Tolar , John Hey
IPC分类号： C07C309/26 , C07C309/19 , C07D207/14 , C07D207/16 , C07C317/50 , C07D401/06 , C07C323/59 , C07D403/12 , C07K5/00 , C07D233/26 , C07D403/06 , C07K5/078 , C07D401/12 , C07D209/20 , C07D295/185 , C07C323/60 , C07D211/58 , C07C309/27 , A61P25/28
摘要： Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
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公开(公告)号：US10590070B2
公开(公告)日：2020-03-17
申请号：US15751547
申请日：2016-08-10
申请人： ALZHEON, INC.
发明人： Petr Kocis , Martin Tolar , John Hey
IPC分类号： C07C309/26 , A61P25/28 , C07C309/19
摘要： Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
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公开(公告)号：US20210315847A1
公开(公告)日：2021-10-14
申请号：US17264477
申请日：2019-07-30
申请人： Alzheon, Inc.
发明人： John Hey , Petr Kocis , Martin Tolar , Neil William Flanzraich
IPC分类号： A61K31/19 , A61K31/185 , A61P25/28
摘要： Tramiprosate and derivatives thereof are provided herein for treating neurodegenerative disorders such as Alzheimer's disease (AD).
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公开(公告)号：US11077095B2
公开(公告)日：2021-08-03
申请号：US16488327
申请日：2018-02-23
申请人： Alzheon, Inc.
发明人： Petr Kocis , Martin Tolar , John Hey
IPC分类号： A61K31/4196 , A61K31/426 , A61K31/44 , A61P25/28 , A61K31/433 , A61K31/505
摘要： Methods of treating a disease characterized by amyloid aggregates are provided herein.
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公开(公告)号：US20180250249A1
公开(公告)日：2018-09-06
申请号：US15758405
申请日：2014-09-09
申请人： ALZHEON, INC.
发明人： Susan Abushakra , Aidan Power , Martin Tolar , John Hey , Jeremy Yu , Petr Kocis
IPC分类号： A61K31/185 , A61P25/28
CPC分类号： A61K31/185 , A61P25/28
摘要： Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate, valyl-3-amino-1-propanesulfonic acid, or a pharmaceutically acceptable salt thereof based upon a combination of APOE4 status and disease severity.
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公开(公告)号：US20230133465A1
公开(公告)日：2023-05-04
申请号：US17673269
申请日：2022-02-16
申请人： Alzheon, Inc.
发明人： Petr Kocis , Martin Tolar , John Hey
IPC分类号： C07C309/26 , C07C309/19 , C07D207/14 , C07D207/16 , C07C317/50 , C07D401/06 , C07C323/59 , C07D403/12 , C07K5/00 , C07D233/26 , C07D403/06 , C07K5/078 , C07D401/12 , C07D209/20 , C07D295/185 , C07C323/60 , C07D211/58 , C07C309/27 , A61P25/28
摘要： Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
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公开(公告)号：US20220062241A1
公开(公告)日：2022-03-03
申请号：US17358471
申请日：2021-06-25
申请人： Alzheon, Inc.
发明人： Petr Kocis , Martin Tolar , John Hey
IPC分类号： A61K31/4196 , A61P25/28 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/505
摘要： Methods of treating a disease characterized by amyloid aggregates are provided herein.
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公开(公告)号：US11053192B2
公开(公告)日：2021-07-06
申请号：US16807747
申请日：2020-03-03
申请人： Alzheon, Inc.
发明人： Petr Kocis , Martin Tolar , John Hey
IPC分类号： C07C309/26 , C07C309/19 , C07D207/14 , C07D207/16 , C07C317/50 , C07D401/06 , C07C323/59 , C07D403/12 , C07D233/26 , C07D403/06 , C07D401/12 , C07D209/20 , C07D295/185 , C07C323/60 , C07D211/58 , C07C309/27 , A61P25/28 , C07K5/00 , C07K5/078
摘要： Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
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