公开(公告)号：US12297260B2

公开(公告)日：2025-05-13

申请号：US17015212

申请日：2020-09-09

Applicant: AMGEN INC.

Inventor： William Gleason Richards ,  Hsieng Sen Lu ,  Hua Zhu Ke ,  Chaoyang Li ,  Frederick W. Jacobsen

IPC: C07K16/18 ,  A61K39/395 ,  C07K16/22 ,  A61K39/00

Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.

公开(公告)号：US10800839B2

公开(公告)日：2020-10-13

申请号：US15841065

申请日：2017-12-13

Applicant: Amgen Inc.

Inventor： William Gleason Richards ,  Hsieng Sen Lu ,  Hua Zhu Ke ,  Chaoyang Li ,  Frederick W. Jacobsen

IPC: C07K16/18 ,  C07K16/22 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.