公开(公告)号：US20230126688A1

公开(公告)日：2023-04-27

申请号：US17929232

申请日：2022-09-01

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/12 ,  A61K47/22 ,  A61K39/395 ,  A61K9/00 ,  A61K38/18

Abstract: The present invention relates to stable aqueous protein formulations. In particular, disclosed herein are therapeutic protein formulations suitable for parenteral administration having one or more antioxidants.

公开(公告)号：US09320797B2

公开(公告)日：2016-04-26

申请号：US13742818

申请日：2013-01-16

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Vergara ,  Jason Ko ,  Tiansheng Li

IPC: A61K39/395 ,  A61K47/22 ,  A61K9/19 ,  A61K47/18 ,  A61K9/00

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

公开(公告)号：US20200276313A1

公开(公告)日：2020-09-03

申请号：US16878385

申请日：2020-05-19

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Vergara ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/24 ,  A61K9/19 ,  A61K47/18 ,  A61K47/22 ,  A61K39/395

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from caritine, creatine or creatinine.

公开(公告)号：US20130121990A1

公开(公告)日：2013-05-16

申请号：US13742818

申请日：2013-01-16

Applicant: Amgen Inc.

Inventor： Christopher James Sloey ,  Camille Vergara ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/22 ,  A61K47/18

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

Abstract translation: 提供了稳定的药物制剂，其包含生物活性蛋白质和选自肉碱，肌酸或肌酸酐的赋形剂。

公开(公告)号：US10653781B2

公开(公告)日：2020-05-19

申请号：US15089036

申请日：2016-04-01

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Gleason ,  Jason Ko ,  Tiansheng Li

IPC: A61K39/395 ,  A61K47/24 ,  A61K9/19 ,  A61K47/18 ,  A61K47/22 ,  A61K9/00

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

公开(公告)号：US20170049895A1

公开(公告)日：2017-02-23

申请号：US15089036

申请日：2016-04-01

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Gleason ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/24 ,  A61K47/18 ,  A61K47/22 ,  A61K39/395 ,  A61K9/19

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

Abstract translation: 提供了稳定的药物制剂，其包含生物活性蛋白质和选自肉碱，肌酸或肌酸酐的赋形剂。