公开(公告)号：US20220357280A1

公开(公告)日：2022-11-10

申请号：US17684968

申请日：2022-03-02

Applicant: Samsung Electronics Co., Ltd. ,  Arizona Board of Regents on behalf of Arizona State University

Inventor： Won Jong Jung ,  Di Wang ,  Vishal Varun Tipparaju ,  Xiaojun Xian ,  Jingjing Yu ,  Kak Namkoong

IPC: G01N21/78 ,  G01N21/25

Abstract: An apparatus for estimating a concentration of a biomarker, may include: an inlet configured to receive the biomarker of an object; a chamber configured to store the biomarker; a sensor cartridge comprising a measurement channel provided as a porous substrate, the measurement channel comprising a probe which is disposed in each pore of the porous substrate and changes in color upon reaction with the biomarker; a light source configured to emit light onto the measurement channel; a detector configured to detect the light incident from the measurement channel; and a processor configured to obtain color change information of the measurement channel based on the light detected by the detector, and estimate the concentration of the biomarker based on the color change information.

公开(公告)号：US20220178834A1

公开(公告)日：2022-06-09

申请号：US17681128

申请日：2022-02-25

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Nongjian Tao ,  Di Wang ,  Chenwen Lin

IPC: G01N21/78 ,  G01N33/00

Abstract: A micro-colorimetric sensor for sensing target chemicals using edge tracking includes a substrate. A plurality of parallel linear channels of porous media is entrenched into the substrate and each linear channel includes a sensing material adapted to sense one of several specific target chemicals in air. The plurality of parallel linear channels is separated by barrier material from the adjacent parallel linear channel where the barrier material blocks diffusion of chemicals from one linear channel to another. A plate is affixed over the substrate top to cover the plurality of parallel linear channels. An air sample is diffused along the micro-colorimetric sensor and color images are captured. An intensity profile is derived from the plurality of color images to determine a maximum and a minimum intensity value along the sensor. A plurality of positions along the sensor is tracked to determine an edge position.

公开(公告)号：US11293875B2

公开(公告)日：2022-04-05

申请号：US16142463

申请日：2018-09-26

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Nongjian Tao ,  Di Wang ,  Chenwen Lin

IPC: G01N21/78 ,  G01N33/00 ,  G01N21/77

Abstract: A micro-colorimetric sensor for sensing target chemicals that converts time sequence information into a spatial distribution of color. By tracking the spatial color distribution, chemical exposure over time is thus detected, which overcomes the limitation of traditional colorimetric sensors. A porous media is coated on a top surface of the substrate. Multiple sensing chemicals are fused in parallel linear channels into the porous media coating. A plate is affixed over the substrate top surface to cover the plurality of parallel linear channels. An air sample is diffused along the porous media to get a clear pattern of spatial color distribution and color images are captured. Optical parameters like gradient of spatial color distribution, intensity, and absorbance, etc., can be tracked to calculate analytes concentrations.

公开(公告)号：US12146836B2

公开(公告)日：2024-11-19

申请号：US17681128

申请日：2022-02-25

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Nongjian Tao ,  Di Wang ,  Chenwen Lin

IPC: G01N21/78 ,  G01N21/77 ,  G01N33/00

Abstract: A micro-colorimetric sensor for sensing target chemicals using edge tracking includes a substrate. A plurality of parallel linear channels of porous media is entrenched into the substrate and each linear channel includes a sensing material adapted to sense one of several specific target chemicals in air. The plurality of parallel linear channels is separated by barrier material from the adjacent parallel linear channel where the barrier material blocks diffusion of chemicals from one linear channel to another. A plate is affixed over the substrate top to cover the plurality of parallel linear channels. An air sample is diffused along the micro-colorimetric sensor and color images are captured. An intensity profile is derived from the plurality of color images to determine a maximum and a minimum intensity value along the sensor. A plurality of positions along the sensor is tracked to determine an edge position.

公开(公告)号：US11543345B2

公开(公告)日：2023-01-03

申请号：US16857660

申请日：2020-04-24

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Nongjian Tao ,  Di Wang

IPC: H01L27/146 ,  G01N21/77 ,  G01N21/25 ,  G01N1/31

Abstract: A colorimetric sensor array includes a CMOS image sensor having a surface including pixels and a multiplicity of colorimetric sensing elements. Each sensing element has a sensing material disposed directly on one or more of the pixels. The colorimetric sensing elements are distributed randomly on the surface of the CMOS image sensor. Fabricating the colorimetric sensor array includes spraying a sensing fluid in the form of droplets directly on a surface of a CMOS image sensor and removing the solvent from the droplets to yield a multiplicity of sensing elements on the surface of the CMOS image sensor. Each droplet covers one or more pixels of the CMOS image sensor with the sensing fluid. The sensing fluid includes a solvent and a sensing material. The droplets are distributed randomly on the surface of the CMOS image sensor.