公开(公告)号：US20190216923A1

公开(公告)日：2019-07-18

申请号：US16244768

申请日：2019-01-10

Applicant: Array BioPharma Inc.

Inventor： Patrice A. Lee ,  David Chantry ,  Shannon L. Winski

IPC: A61K39/395 ,  A61P35/00 ,  A61K31/4184 ,  A61P35/04 ,  A61K9/00

CPC classification number: A61K39/3955 ,  A61K9/0019 ,  A61K31/4184 ,  A61K2039/54 ,  A61K2039/545 ,  A61P35/00 ,  A61P35/04

Abstract: This invention relates to a method of treating cancer by administering to a patient in need thereof, over a period of time, therapeutic agents that consist essentially of a MEK inhibitor which is binimetinib or a pharmaceutically acceptable salt thereof, and a PD-1 binding antagonist, to a patient in need thereof.

公开(公告)号：US20190211102A1

公开(公告)日：2019-07-11

申请号：US16244827

申请日：2019-01-10

Applicant: Array BioPharma Inc.

Inventor： Patrice A. Lee ,  David Chantry ,  Shannon L. Winski

IPC: C07K16/28 ,  A61P35/04 ,  A61K9/00 ,  A61K31/4439

CPC classification number: C07K16/2818 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/4439 ,  A61P35/04

Abstract: This invention relates to a method of treating cancer by administering a combination therapy comprising a combination of CSF-1R inhibitor, which is ARRY-382 or a pharmaceutically acceptable salt thereof, and a PD-1 binding antagonist, to a patient in need thereof.