公开(公告)号：US10561654B2

公开(公告)日：2020-02-18

申请号：US15921306

申请日：2018-03-14

Applicant: Array BioPharma Inc.

Inventor： Daya Verma ,  Yogita Krishnamachari ,  Xiaohong Shen ,  Hanchen Lee ,  Ping Li ,  Rajinder Singh ,  LayChoo Tan

IPC: A61K31/506 ,  A61K9/20 ,  A61K9/48 ,  A61K9/00 ,  A61K9/28

Abstract: This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (COMPOUND A) and the use of these formulations for treating proliferative diseases, such as solid tumor diseases.

公开(公告)号：US20190054086A1

公开(公告)日：2019-02-21

申请号：US15921306

申请日：2018-03-14

Applicant: Array BioPharma Inc.

Inventor： Daya Verma ,  Yogita Krishnamachari ,  Xiaohong Shen ,  Hanchen Lee ,  Ping Li ,  Rajinder Singh ,  LayChoo Tan

IPC: A61K31/506 ,  A61K9/20 ,  A61K9/00 ,  A61K9/28 ,  A61K9/48

Abstract: This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2- yl)carbamate (COMPOUND A) and the use of these formulations for treating proliferative diseases, such as solid tumor diseases.

公开(公告)号：US09763941B2

公开(公告)日：2017-09-19

申请号：US15179190

申请日：2016-06-10

Applicant: Array BioPharma, Inc.

Inventor： Daya Verma ,  Yogita Krishnamachari ,  Xiaohong Shen ,  Hanchen Lee ,  Ping Li ,  Rajinder Singh ,  LayChoo Tan

IPC: A61K31/506 ,  A61K9/20 ,  A61K9/48 ,  A61K9/00

CPC classification number: A61K31/506 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/282 ,  A61K9/284 ,  A61K9/2866 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866

Abstract: This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methyl -sulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (COMPOUND A) and the use of these formulations for treating proliferative diseases, such as solid tumor diseases.

公开(公告)号：US10258622B2

公开(公告)日：2019-04-16

申请号：US15452239

申请日：2017-03-07

Applicant: Array BioPharma, Inc.

Inventor： Daya Verma ,  Yogita Krishnamachari ,  Xiaohong Shen ,  Hanchen Lee ,  Ping Li ,  Rajinder Singh ,  LayChoo Tan

IPC: A61K31/506 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48 ,  A61K9/00

Abstract: This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methyl-sulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (COMPOUND A) and the use of these formulations for treating proliferative diseases, such as solid tumor diseases.

公开(公告)号：US20170202837A1

公开(公告)日：2017-07-20

申请号：US15452239

申请日：2017-03-07

Applicant: Array BioPharma, Inc.

Inventor： Daya Verma ,  Yogita Krishnamachari ,  Xiaohong Shen ,  Hanchen Lee ,  Ping Li ,  Rajinder Singh ,  LayChoo Tan

IPC: A61K31/506 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48

CPC classification number: A61K31/506 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/282 ,  A61K9/284 ,  A61K9/2866 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866

Abstract: This invention relates to solid oral pharmaceutical formulations or(S)-methyl ((4(4-(3-(5-chtoro-2-fluoro-3-(methyl-sutfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (COMPOUND A) and the use of these formulations for treating proliferative diseases, such as solid tumor diseases.