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1.发明申请公开(公告)号：US20210077493A1
公开(公告)日：2021-03-18
申请号：US16942094
申请日：2020-07-29
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61K31/437 , A61P35/00 , C07D471/04 , A61K45/06
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5 -a]pyridin-7-yloxy)-3 -methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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2.发明申请公开(公告)号：US20180140603A1
公开(公告)日：2018-05-24
申请号：US15861444
申请日：2018-01-03
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61K45/06 , C07D471/04
CPC classification number: A61K31/517 , A61K31/437 , A61K45/06 , A61P35/00 , C07D471/04
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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3.发明授权Crystalline forms of 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride 有权1-（3-叔丁基-1-对甲苯基-1H-吡唑-5-基）-3-（5-氟-2-（1-（2-羟基乙基）-1H-吲唑-5-基） 氧基）苄基）脲盐酸盐公开(公告)号：US09278936B2
公开(公告)日：2016-03-08
申请号：US14382178
申请日：2013-02-27
Applicant: Array BioPharma Inc.
Inventor： Alisha B. Arrigo , Donald T. Corson , Coralee G. Mannila
IPC: C07D231/56 , A61K31/4155
CPC classification number: C07D231/56 , A61K31/4155 , Y02A50/411 , Y02A50/463
Abstract: Provided herein is a hydrogen chloride salt of 1-(3-/t?r/-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea, crystalline forms of 1-(3-½^butyl-1^-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride, processes for the preparation of said crystalline forms, pharmaceutical compositions containing a crystalline form of 1-(3-r
Abstract translation: 本文提供的是1-（3-叔丁基-1-叔丁基-1-对甲苯基-1H-吡唑-5-基）-3-（5-氟-2-（1-（2 - 羟基乙基）-1H-吲唑-5-基氧基）苄基）脲，1-（3 - 1/2丁基-1'-甲苯基-1H-吡唑-5-基）-3-（5-氟-2 - （1-（2-羟乙基）-1H-吲唑-5-基氧基）苄基）脲盐酸盐，制备所述结晶形式的方法，含有1-（3-r 丁基-1-对甲苯基-1H-吡唑-5-基）-3-（5-氟-2-（1-（2-羟乙基）-1H-吲唑-5-基氧基）苄基）脲盐酸盐形式B ，所述组合物的制备方法，通过所述方法制备的药物组合物，以及所述组合物在治疗各种疾病和病症中的用途。
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4.发明授权公开(公告)号：US11571424B2
公开(公告)日：2023-02-07
申请号：US16942094
申请日：2020-07-29
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61K31/437 , A61P35/00 , C07D471/04 , A61K45/06
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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5.发明申请POLYMORPHS OF ARRY-380, A SELECTIVE HER 2 INHIBITOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权ARRY-380的多聚体，选择性的2抑制剂和含有它们的药物组合物公开(公告)号：US20160175309A1
公开(公告)日：2016-06-23
申请号：US14923172
申请日：2015-10-26
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61K45/06
CPC classification number: A61K31/517 , A61K31/437 , A61K45/06 , A61P35/00 , C07D471/04
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
Abstract translation: N 4 - （4 - （[1,2,4]三唑并[1,5-a]吡啶-7-基氧基）-3-甲基苯基）-N6-（4,4-二甲基-4,5-二氢恶唑-2-基） 吡啶-2-基）喹唑啉-4,6-二胺。 还公开了制备多晶型物的方法和包含多晶型物的药物组合物。
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Patent Agency Ranking
6.发明公开公开(公告)号：US20230241066A1
公开(公告)日：2023-08-03
申请号：US18092731
申请日：2023-01-03
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61P35/00 , C07D471/04 , A61K31/437 , A61K45/06
CPC classification number: A61K31/517 , A61P35/00 , C07D471/04 , A61K31/437 , A61K45/06
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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![POLYMORPHS OF ARRY-380, A SELECTIVE HER[[B]]2 INHIBITOR AND PHARMACEUTICAL COMPOSITIONS CONT[[l]]AINING THEM](/abs-image/US/2019/05/02/US20190125749A1/abs.jpg.150x150.jpg)
7.发明申请公开(公告)号：US20190125749A1
公开(公告)日：2019-05-02
申请号：US16169937
申请日：2018-10-24
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61K45/06 , A61K31/437 , A61P35/00 , C07D471/04
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4, 5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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8.发明授权公开(公告)号：US09889134B2
公开(公告)日：2018-02-13
申请号：US14923172
申请日：2015-10-26
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: C07D471/04 , A61K31/437 , A61K31/517 , A61K45/06 , A61P35/00
CPC classification number: A61K31/517 , A61K31/437 , A61K45/06 , A61P35/00 , C07D471/04
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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9.发明授权公开(公告)号：US10765678B2
公开(公告)日：2020-09-08
申请号：US16169937
申请日：2018-10-24
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: C07D471/04 , A61K31/437 , A61K31/517 , A61P35/00 , A61K45/06
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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10.发明授权公开(公告)号：US10143692B2
公开(公告)日：2018-12-04
申请号：US15861444
申请日：2018-01-03
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: C07D471/04 , A61K31/437 , A61K31/517 , A61P35/00 , A61K45/06
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
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