公开(公告)号：US20140309226A1

公开(公告)日：2014-10-16

申请号：US14359036

申请日：2012-11-14

Applicant: Array BioPharma Inc.

Inventor： Jay Bradford Fell ,  John P. Fischer ,  Ronald J. Hinklin

IPC: C07D417/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D417/14 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, in which X1, X2, R3, R4, R5, Rx, R7, R9, R10 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Abstract translation: 其中X1，X2，R3，R4，R5，Rx，R7，R9，R10和n具有本说明书中给出的含义的式I化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗 或预防诸如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症等疾病。