公开(公告)号：US20230041385A1

公开(公告)日：2023-02-09

申请号：US17849621

申请日：2022-06-25

Applicant: Array BioPharma Inc.

Inventor： Bryan Daniel ELLIS ,  Erik James HICKEN ,  Ellen Ruth LAIRD ,  Nicholas Charles LAZZARA ,  Bradley Jon NEWHOUSE ,  Spencer Phillip PAJK ,  Rachel Zoe Rosen ,  Russell Andrew Shelp

IPC: A61K31/519 ,  C07D519/00 ,  C07D471/04 ,  A61K31/551 ,  A61K31/55 ,  A61K31/5386 ,  A61K39/395 ,  A61K31/704 ,  A61K31/337 ,  A61K38/14 ,  A61K31/506 ,  A61K31/502 ,  A61K31/655 ,  A61K31/573 ,  A61K31/7048 ,  A61K31/44

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein A, L2, R1, R2, R3, R4, and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts, and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.