公开(公告)号：US20150057448A1

公开(公告)日：2015-02-26

申请号：US14494430

申请日：2014-09-23

Applicant: Array BioPharma Inc.

Inventor： Thomas Daniel Aicher ,  Steven Armen Boyd ,  Mark Joseph Chicarelli ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Indrani W. Gunawardana ,  Ronald Jay Hinklin ,  Ajay Singh ,  Timothy M. Turner ,  Eli M. Wallace

IPC: C07D401/14 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: Provided are intermediates having the formulas wherein R2, R3, and L are as defined in the specification, which are useful in the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives.

Abstract translation: 提供具有下式的中间体其中R2，R3和L如说明书中所定义，其可用于制备吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物。

公开(公告)号：US09079890B2

公开(公告)日：2015-07-14

申请号：US14494430

申请日：2014-09-23

Applicant: Array BioPharma Inc.

Inventor： Thomas Daniel Aicher ,  Steven Armen Boyd ,  Mark Joseph Chicarelli ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Indrani W. Gunawardana ,  Ronald Jay Hinklin ,  Ajay Singh ,  Timothy M. Turner ,  Eli M. Wallace

IPC: C07D417/00 ,  C07D401/14 ,  C07D417/14 ,  C07D213/75 ,  C07D417/12 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: Provided are intermediates having the formulas wherein R2, R3, and L are as defined in the specification, which are useful in the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives.

Abstract translation: 提供具有下式的中间体其中R2，R3和L如说明书中所定义，其可用于制备吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物。

公开(公告)号：US20140256756A1

公开(公告)日：2014-09-11

申请号：US14355804

申请日：2012-10-30

Applicant: Array BioPharma Inc.

Inventor： Thomas Daniel Aicher ,  Josef Roland Benscik ,  Steven Armen Boyd ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John Peter Fischer ,  Ronald Jay Hinklin ,  Scott Pratt ,  Ajay Singh ,  Timothy M. Turner

IPC: C07D417/14 ,  C07D413/14

CPC classification number: C07D417/14 ,  C07D413/14

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, X3, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Abstract translation: 其中X1，X2，X3，L，R3，R4，R5，R7和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗或预防 的疾病，例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症。