公开(公告)号：US12208095B2

公开(公告)日：2025-01-28

申请号：US17001519

申请日：2020-08-24

Applicant: Arvinas Operations, Inc.

Inventor： Andrew P. Crew ,  John Flanagan ,  Sheryl Maxine Gough ,  Royal J. Haskell, III ,  Marcia Dougan Moore ,  Yimin Qian ,  Ian Charles Anthony Taylor ,  Jing Wang

IPC: A61K31/496 ,  A61K31/519 ,  A61K47/02 ,  A61K47/22 ,  A61K47/26 ,  A61K47/38 ,  A61P35/00

Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2− breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.