公开(公告)号：US20160046572A1

公开(公告)日：2016-02-18

申请号：US14778771

申请日：2014-03-27

Applicant: BASF SE

Inventor： Timo FRASSETTO ,  Harald JOCKERS ,  Christopher KORADIN ,  Thomas ZIERKE ,  Karsten KOERBER

IPC: C07C381/10 ,  C07D401/04

CPC classification number: C07C381/10 ,  A01N37/28 ,  A01N43/56 ,  C07C2601/02 ,  C07D401/04 ,  C07D409/14

Abstract: The present invention relates to a process for preparing a compound of the formulae (Ia) or (Ib), or a mixture thereof, wherein R1 and R2 independently of one another are hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C10-cycloalkyl, C3-C10-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl or together represent an aliphatic chain, or the like; A− is HSO4− or 1/2 SO42−; the process comprising the reaction of a sulfide of formula SR1R2 with hydroxylamineO-sulfonic acid of formula; wherein the reaction is carried out in an aqueous medium in the presence of a base. The present invention also relates to a process for preparing a compound of the formula (IV), wherein R3 is halogen, cyano, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C8-alkenyl, C2-C8-haloalkenyl, C1-C8-alkoxy, phenyl, or the like; R4 is hydrogen, C1-C10-alkyl, C1-C10-haloalkyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C2-C10-alkenyl, C2-C10-haloalkenyl, phenyl, or the like; p is 0, 1, 2, 3 or 4; the process comprising: (i) providing the compound of the formulae (Ia) or (Ib), or a mixture thereof, (ii) reacting a compound of the formulae (Ia) or (Ib), or a mixture thereof, obtained in step (i) with a compound of the formula (V) in the presence of a base,

Abstract translation: 本发明涉及制备式（Ia）或（Ib）化合物或其混合物的方法，其中R 1和R 2彼此独立地是氢，C 1 -C 10 - 烷基，C 1 -C 10 - 卤代烷基， C 3 -C 10 - 环烷基，C 3 -C 10 - 卤代环烷基，C 2 -C 10 - 烯基，C 2 -C 10 - 卤代烯基或一起代表脂族链等; A-是HSO4-或1/2 SO42-; 该方法包括式SR 1 R 2的硫化物与式的羟胺O-磺酸的反应; 其中反应在碱的存在下在水性介质中进行。 本发明还涉及制备式（IV）化合物的方法，其中R 3是卤素，氰基，C 1 -C 8 - 烷基，C 1 -C 8 - 卤代烷基，C 3 -C 8 - 环烷基，C 3 -C 8 - 卤代环烷基， C 2 -C 8 - 烯基，C 2 -C 8 - 卤代烯基，C 1 -C 8 - 烷氧基，苯基等; R4是氢，C1-C10-烷基，C1-C10-卤代烷基，C3-C8-环烷基，C3-C8-卤代环烷基，C2-C10-烯基，C2-C10-卤代烯基，苯基等; p是0，1，2，3或4; 该方法包括：（i）提供式（Ia）或（Ib）化合物或其混合物，（ii）使式（Ia）或（Ib）化合物或其混合物 步骤（i）与式（Ⅴ）化合物在碱的存在下反应，