公开(公告)号：US20130041147A1

公开(公告)日：2013-02-14

申请号：US13653615

申请日：2012-10-17

Applicant: BASF SE

Inventor： Thomas ZIERKE ,  Volker MAYWALD ,  Michael RACK ,  Sebastian Peer SMIDT ,  Michael KEIL ,  Bernd WOLF ,  Christopher KORADIN

IPC: C07D231/14 ,  C07D265/30 ,  C07D295/145

CPC classification number: C07D231/14 ,  C07C229/30 ,  C07D295/145

Abstract: The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3- oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.

Abstract translation: 本发明涉及一种制备二氟甲基取代的吡唑-4-基羧酸及其酯的式（I）的2-（氨基亚甲基）-4,4-二氟-3-氧代异丁酯，其中R1，R2和 R 3彼此独立地是C 1 -C 6 - 烷基，C 1 -C 6 - 卤代烷基，C 2 -C 6 - 烯基，C 3 -C 10 - 环烷基或苄基或NR 2 R 3是5-至10-元杂环基， 式（I）的化合物，其中适当的3-氨基丙烯酸酯与二氟乙酰氟反应，以及在制备二氟甲基取代的吡唑-4-基羧酸及其酯的方法中使用式（I）的化合物。