公开(公告)号：US20210380569A1

公开(公告)日：2021-12-09

申请号：US17288976

申请日：2019-10-28

Applicant: BASF SE

Inventor： Roland Goetz ,  Michael Rack ,  Martin John McLaughlin ,  Harish Shinde ,  Ritesh Karalkar ,  Kailaskumar Borate ,  Karsten Koerber ,  Arun Narine ,  Nikolas Huwyler

IPC: C07D413/04 ,  B01J31/02

Abstract: The invention relates to a process for preparing optically enriched isoxazoline compounds of formula (I), wherein the variables are as defined in the specification, and the shown enantiomer has at least 80% ee; by oxo-Michael addition of hydroxyl amine or its salt to an enone of formula (II), wherein the variables have the meanings given for formula (I), in the presence of a catalyst of formula (III) and a base.