公开(公告)号：US10766859B2

公开(公告)日：2020-09-08

申请号：US16471144

申请日：2017-12-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Mueller

IPC: C07D213/26 ,  C07D213/40 ,  C07D213/60 ,  C07D213/61

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of Raney catalysts, in particular Raney nickel or cobalt.

公开(公告)号：US09988353B2

公开(公告)日：2018-06-05

申请号：US15033987

申请日：2014-11-11

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed Moradi ,  Thomas Himmler ,  Thomas Norbert Mueller ,  Albert Schnatterer ,  Guenter Schlegel

IPC: C07D213/56 ,  C07D213/89 ,  C07D213/38 ,  C07D213/57

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.