公开(公告)号：US20240216330A1

公开(公告)日：2024-07-04

申请号：US18285123

申请日：2022-04-01

Applicant: BIOGEN MA INC.

Inventor： Michael Joseph Palte ,  Brian T. Hopkins ,  Matthew P. Scaramozza ,  Michael Christian Mingueneau ,  Alex Pellerin ,  Chelsea R. Parker Harp ,  Catherine Barbey

IPC: A61K31/4015 ,  A61K31/225 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/506 ,  A61P25/28 ,  A61P37/00

CPC classification number: A61K31/4015 ,  A61K31/225 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/506 ,  A61P25/28 ,  A61P37/00

Abstract: The present disclosure provides combination therapies for treating an autoimmune disease in a subject in need thereof. The methods comprise administering to the subject an effective amount of a BTK inhibitor in combination with an effective amount of a fumaric acid ester (FAE). The autoimmune disease can be treated include, for example, multiple sclerosis (MS), lupus, rheumatoid arthritis (RA), Pemphigus Vugaris (PV), neuromyelitis optica (NMO), myasthenia gravis (MG), chronic inflammatory demyelinating polyneuropathy (CIDP), anti-NMDA receptor encephalitis, or Sjogren's disease.