公开(公告)号：US20170247395A1

公开(公告)日：2017-08-31

申请号：US15593534

申请日：2017-05-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jaques Banville ,  Roger Remillard ,  Edward H. Ruediger ,  Daniel H. Deon ,  Marc Gagnon ,  Laurence Dube ,  Julia Guy ,  Eldon Scott Priestly ,  Shoshana L. Posy ,  Brad D. Maxwell ,  Pancras C. Wong ,  R. Michael Lawrence ,  Michael M. Miller

IPC: C07D513/04 ,  C07B59/00 ,  A61K31/433 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/541 ,  A61K31/553 ,  A61K31/5386 ,  C07D519/00 ,  A61K31/435 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/55 ,  A61K51/04

CPC classification number: C07D513/04 ,  A61K31/433 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61K45/06 ,  A61K51/0453 ,  C07B59/002 ,  C07B2200/05 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.