公开(公告)号：US20160000771A1

公开(公告)日：2016-01-07

申请号：US14770702

申请日：2014-03-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： KEVIN PEESE ,  ZHONGYU WANG ,  JOHN F. KADOW ,  B. NARASIMHULU NAIDU

IPC: A61K31/4545 ,  C07D471/04 ,  A61K45/06

CPC classification number: A61K31/4545 ,  A61K45/06 ,  C07D471/04

Abstract: The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

公开(公告)号：US20130030005A1

公开(公告)日：2013-01-31

申请号：US13624222

申请日：2012-09-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： TAO WANG ,  ZHONGXING ZHANG ,  NICHOLAS A. MEANWELL ,  JOHN F. KADOW ,  ZHIWEI YIN ,  QUIFEN MAY XUE ,  ALICIA REGUEIRO-REN ,  JOHN D. MATISKELLA ,  YASUTSUGU UEDA

IPC: A61K31/496 ,  A61P31/18

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K45/06 ,  C07D491/048

Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.