公开(公告)号：US10316035B2

公开(公告)日：2019-06-11

申请号：US15756373

申请日：2016-08-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew Quoc Viet ,  Nicholas Ronald Wurtz ,  Scott A. Shaw ,  Ellen K. Kick ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty

IPC: C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein A, Y and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US20180244671A1

公开(公告)日：2018-08-30

申请号：US15756373

申请日：2016-08-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew Quoc Viet ,  Nicholas Ronald Wurtz ,  Scott A. Shaw ,  Ellen K. Kick ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein A, Y and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US09174974B2

公开(公告)日：2015-11-03

申请号：US14405507

申请日：2013-06-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiaojun Zhang ,  Peter Glunz ,  Eldon Scott Priestley ,  James A. Johnson ,  Nicholas Ronald Wurtz ,  Vladimir Ladziata

IPC: C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D273/02 ,  C07D413/14 ,  C07D417/14 ,  C07F9/6558

CPC classification number: C07D413/12 ,  C07D273/02 ,  C07D401/12 ,  C07D413/14 ,  C07D417/14 ,  C07F9/65583

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可以用作药物的因子VIIa抑制剂。

公开(公告)号：US20150148313A1

公开(公告)日：2015-05-28

申请号：US14405507

申请日：2013-06-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiaojun Zhang ,  Peter Glunz ,  Eldon Scott Priestley ,  James A. Johnson ,  Nicholas Ronald Wurtz ,  Vladimir Ladziata

IPC: C07D413/12 ,  C07F9/6558 ,  C07D413/14 ,  C07D401/12 ,  C07D417/14

CPC classification number: C07D413/12 ,  C07D273/02 ,  C07D401/12 ,  C07D413/14 ,  C07D417/14 ,  C07F9/65583

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的因子VIIa抑制剂。