公开(公告)号：US20220064186A1

公开(公告)日：2022-03-03

申请号：US17415237

申请日：2019-12-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Roxana F. Schlam ,  Nicolas Cuniere ,  Victoria A. Mbachu ,  Zhongping Shi ,  Petinka I. Vlahova

IPC: C07D513/04 ,  C07C55/10 ,  C07C59/265 ,  A61K45/06 ,  A61K31/433 ,  A61P7/02

Abstract: The present invention relates to co-crystals of the compound of formula (I), wherein the co-former molecule is succinic acid or citric acid, processes for the preparation of the co-crystal, pharmaceutical compositions thereof, and methods of using the co-crystals for treating or preventing thromboembolic disorders.

公开(公告)号：US20250026767A1

公开(公告)日：2025-01-23

申请号：US18908888

申请日：2024-10-08

Applicant: Bristol-Myers Squibb Company

Inventor： Roxana F. Schlam ,  Nicolas Cuniere ,  Victoria A. Mbachu ,  Zhongping Shi ,  Petinka I. Vlahova

IPC: C07D513/04 ,  A61K31/433 ,  A61K45/06 ,  A61P7/02 ,  C07C55/10 ,  C07C59/265

Abstract: The present invention relates to co-crystals of the compound of formula (I). wherein the co-former molecule is succinic acid or citric acid. processes for the preparation of the co-crystal. pharmaceutical compositions thereof, and methods of using the co-crystals for treating or preventing thromboembolic disorders.

公开(公告)号：US12129264B2

公开(公告)日：2024-10-29

申请号：US17415237

申请日：2019-12-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Roxana F. Schlam ,  Nicolas Cuniere ,  Victoria A. Mbachu ,  Zhongping Shi ,  Petinka I. Vlahova

IPC: C07D513/04 ,  A61K31/433 ,  A61K45/06 ,  A61P7/02 ,  C07C55/10 ,  C07C59/265

CPC classification number: C07D513/04 ,  A61K31/433 ,  A61K45/06 ,  A61P7/02 ,  C07C55/10 ,  C07C59/265 ,  C07B2200/13

Abstract: The present invention relates to co-crystals of the compound of formula (I), wherein the co-former molecule is succinic acid or citric acid, processes for the preparation of the co-crystal, pharmaceutical compositions thereof, and methods of using the co-crystals for treating or preventing thromboembolic disorders.