公开(公告)号：US09580422B2

公开(公告)日：2017-02-28

申请号：US15031301

申请日：2014-10-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yaofeng Cheng ,  Weiqi Chen ,  Brad D. Maxwell ,  Bach D. Tran ,  Jun Li

IPC: A61K31/44 ,  C07D401/00 ,  C07D471/04 ,  C07B59/00 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  C07B59/002 ,  C07B2200/05

Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein R* is an isotopically labeled hydroxypropyl moiety.

Abstract translation: 提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。 这些新的式I化合物或其立体异构体或其药学上可接受的盐，其中R *是同位素标记的羟丙基部分。

公开(公告)号：US20160257680A1

公开(公告)日：2016-09-08

申请号：US15031301

申请日：2014-10-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yaofeng Cheng ,  Weiqi Chen ,  Brad D. Maxwell ,  Bach D. Tran ,  Jun Li

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  C07B59/002 ,  C07B2200/05

Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein R* is an isotopically labeled hydroxypropyl moiety.

Abstract translation: 提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。 这些新的式I化合物或其立体异构体或其药学上可接受的盐，其中R *是同位素标记的羟丙基部分。