公开(公告)号：US20240335511A1

公开(公告)日：2024-10-10

申请号：US18268124

申请日：2021-12-20

Applicant: BioNTech SE

Inventor： Ugur SAHIN ,  Alexander MUIK ,  Lena Mareen KRANZ ,  Mathias VORMEHR ,  Sina FELLERMEIER-KOPF ,  Jan DIEKMANN ,  David EISEL

IPC: A61K38/20 ,  A61K9/51 ,  A61K38/38 ,  A61K48/00 ,  A61P35/00 ,  C07K14/54 ,  C07K14/55 ,  C07K14/765

CPC classification number: A61K38/2046 ,  A61K9/5146 ,  A61K38/2013 ,  A61K38/38 ,  A61K48/0041 ,  A61P35/00 ,  C07K14/5418 ,  C07K14/55 ,  C07K14/765 ,  C07K2319/31

Abstract: This disclosure relates to the field of therapeutic RNA to treat cancer, in particular advanced solid tumors such as metastatic (Stage IV) or unresectable localized cancer. Disclosed herein are compositions, uses, and methods for treatment of cancers. Administration of therapeutic RNAs to a patient having cancer disclosed herein can reduce tumor size, prolong time to progressive disease, and/or protect against metastasis and/or recurrence of the tumor and ultimately extend survival time.