公开(公告)号：US20230183769A1

公开(公告)日：2023-06-15

申请号：US17893742

申请日：2022-08-23

Applicant: BioNTech SE

Inventor： Irena Rabe ,  Maximilian Buff ,  Thomas Ziegenhals ,  Johanna Drögemüller ,  Andreas Kuhn ,  Stephanie Fesser ,  Rodney Gene Combs ,  Nicole Eschmann ,  Jennifer Ann Schoborg Romine ,  Jenna Kathryn Williamson

IPC: C12P19/34 ,  C12N9/12

CPC classification number: C12P19/34 ,  C12N9/1247

Abstract: The present disclosure provides technologies for in vitro transcription reactions, particularly for production of pharmaceutical grade RNA, and in some embodiments for large scale production.

公开(公告)号：US20240110214A1

公开(公告)日：2024-04-04

申请号：US18266135

申请日：2021-12-07

Applicant: BioNTech SE

Inventor： Thomas Ziegenhals ,  Andreas Kuhn ,  Stephanie Fesser

IPC: C12P19/34 ,  A61K31/7115

CPC classification number: C12P19/34 ,  A61K31/7115

Abstract: The present disclosure provides technologies for performing in vitro transcription that can generate product RNA preparations with reduced levels of certain contaminants (e.g., aberrant products), and particularly of double-stranded RNA (dsRNA).