公开(公告)号：US20220089745A1

公开(公告)日：2022-03-24

申请号：US17353402

申请日：2021-06-21

Applicant: Biogen MA Inc.

Inventor： Bradley Pearse ,  Joe Salas ,  Robert Peters ,  Christilyn Graff

IPC: C07K16/28 ,  C07K14/745 ,  C12N5/078 ,  C12N9/64 ,  G01N33/569

Abstract: Antibodies and antigen-binding antibody fragments that bind to GPIIb/IIIa and chimeric polypeptides comprising these binding molecules are disclosed. Some of these antibodies and antigen-binding antibody fragments preferentially bind GPIIb/IIIa on activated platelets while others do not show a preference for binding GPIIb/IIIa on resting versus activated platelets. Some of these antibodies and antibody fragments do not inhibit the interaction of GPIIb/IIIa with fibrinogen, while some others do. The disclosed antibodies do not induce platelet activation. Some of these antibodies and antigen-binding antibody fragments are useful in targeting therapeutic agents such as dotting factors to platelets while others are useful in reducing platelet aggregation and/or thrombus formation.

公开(公告)号：US20170342152A1

公开(公告)日：2017-11-30

申请号：US15521683

申请日：2015-10-30

Applicant: Biogen MA Inc.

Inventor： Bradley Pearse ,  Joe Salas ,  Robert Peters ,  Christilyn Graff

IPC: C07K16/28 ,  C12N5/078 ,  C12N9/64 ,  G01N33/569

CPC classification number: C07K16/2848 ,  C07K14/745 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/35 ,  C12N5/0644 ,  C12N9/6437 ,  G01N33/56966

Abstract: Antibodies and antigen-binding antibody fragments that bind to GPIIb/IIIa and chimeric polypeptides comprising these binding molecules are disclosed. Some of these antibodies and antigen-binding antibody fragments preferentially bind GPIIb/IIIa on activated platelets while others do not show a preference for binding GPIIb/IIIa on resting versus activated platelets. Some of these antibodies and antibody fragments do not inhibit the interaction of GPIIb/IIIa with fibrinogen, while some others do. The disclosed antibodies do not induce platelet activation. Some of these antibodies and antigen-binding antibody fragments are useful in targeting therapeutic agents such as clotting factors to platelets while others are useful in reducing platelet aggregation and/or thrombus formation.