公开(公告)号：US20220195052A1

公开(公告)日：2022-06-23

申请号：US17599716

申请日：2020-04-08

Applicant: Biogen MA Inc.

Inventor： Christilyn Graff ,  Christina Palmer ,  Brett Blakeley ,  Tracey Mullen ,  Agnes Gardet

IPC: C07K16/28

Abstract: Anti-integrin antibodies are disclosed. Also disclosed are methods of using the antibodies to treat or prevent disorders such as fibrotic diseases, cancer, ophthalmology disorders, and NAFLD. Further disclosed are methods of selecting an antibody that specifically binds to αvβ{umlaut over (í)}, or that binds to αvβ{umlaut over (í)} and αvβó, or that binds to one or more members of the RGD sub-family of integrins.