公开(公告)号：US20220072135A1

公开(公告)日：2022-03-10

申请号：US17405219

申请日：2021-08-18

申请人： The Administrators of the Tulane Educational Fund ,  Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Donghui Zhang ,  Vijay T. John ,  Yueheng Zhang ,  Sunting Xuan

IPC分类号： A61K47/34 ,  C08G69/00

摘要： A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyimide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery.

公开(公告)号：US11123433B2

公开(公告)日：2021-09-21

申请号：US16306429

申请日：2017-02-07

申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

发明人： Donghui Zhang ,  Vijay John ,  Yueheng Zhang ,  Sunting Xuan

IPC分类号： C08G69/00 ,  A61K47/34 ,  A01N37/18

摘要： A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery.

公开(公告)号：US10519278B2

公开(公告)日：2019-12-31

申请号：US15687397

申请日：2017-08-25

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Donghui Zhang ,  Jinbao Cao ,  Brandon Chan ,  David Siefker

IPC分类号： C08G69/42 ,  C08G69/00 ,  C08G69/04 ,  C08G69/10

摘要： Various embodiments disclosed relate to a method of forming a polypeptide. The method includes contacting a first amino acid-derived N-thiocarboxyanhydrosulfide monomer as a crystalline solid with a polymerization initiator (e.g., in an alkane suspension) to give a polypeptide product. The method further includes contacting the polypeptide product with a second amino acid-derived N-thiocarboxyanhydrosulfide monomer in an alkane suspension.

公开(公告)号：US20180057634A1

公开(公告)日：2018-03-01

申请号：US15687397

申请日：2017-08-25

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Donghui Zhang ,  Jinbao Cao ,  Brandon Chan ,  David Siefker

IPC分类号： C08G69/00 ,  C08G69/42

CPC分类号： C08G69/00 ,  C08G69/04 ,  C08G69/10 ,  C08G69/42

摘要： Various embodiments disclosed relate to a method of forming a polypeptide. The method includes contacting a first amino acid-derived N-thiocarboxyanhydrosulfide monomer as a crystalline solid with a polymerization initiator (e.g., in an alkane suspension) to give a polypeptide product. The method further includes contacting the polypeptide product with a second amino acid-derived N-thiocarboxyanhydrosulfide monomer in an alkane suspension.