公开(公告)号：US20190015545A1

公开(公告)日：2019-01-17

申请号：US16033303

申请日：2018-07-12

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Bruce R. Forsyth ,  Hong Cao ,  Matthew R. DeWitt ,  Heidi Schwanz

IPC: A61L24/02 ,  A61L24/00 ,  A61L24/06 ,  A61L24/04

Abstract: In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.

公开(公告)号：US20190254740A1

公开(公告)日：2019-08-22

申请号：US16279438

申请日：2019-02-19

Applicant: Boston Scientific Scimed, Inc.

Inventor： Vijay Koya ,  Elizabeth M. Annoni ,  Bryan A. Clark ,  Bruce Forsyth ,  Hong Cao ,  Matthew R. DeWitt ,  Kyle H. Srivastava

IPC: A61B18/14 ,  A61M37/00 ,  G16H20/17

Abstract: Devices, systems, and methods for regulating glucose levels, including treating diabetes, in accordance with the present disclosure may include a catheter having an expandable or inflatable portion, one or more electrodes disposed on the expandable or inflatable portion of the catheter, wherein the electrodes are configured to deliver energy to a patient's gastrointestinal tract, and a drug delivery mechanism for delivering a drug therapy subsequent to energy delivery by the electrodes. A method for regulating glucose levels according to the present disclosure may include inserting a catheter into a patient's gastrointestinal tract, positioning the catheter in a duodenum of the patient's gastrointestinal tract, expanding or inflating a portion of the catheter in the duodenum, the expandable or inflatable portion of the catheter including electrodes, applying energy to the duodenum via the electrodes to ablate tissue of the duodenum, and delivering a drug therapy to the ablated tissue of the duodenum.