公开(公告)号：US11497934B2

公开(公告)日：2022-11-15

申请号：US16302008

申请日：2017-10-27

Applicant: Brainlab AG

Inventor： Cornelis Kamerling ,  Stefan Schell ,  Andreas Schatti

IPC: A61N5/10 ,  G16H20/40 ,  G16H50/50 ,  G16H30/20 ,  G16H40/63

Abstract: Disclosed is a computer-implemented method of determining a treatment plan, encompassing acquiring patient image data, acquiring target data describing targets, acquiring position data describing control points which define one or more arcs, and determining target projection data which describes outlines of the target in a beam's-eye view. Margin data is acquired. For the outlines, margins are applied to determine auxiliary outlines. Beam shaping device data is determined describing configurations of the collimator leaves so that irradiation of the auxiliary outlines is enabled. Based on these configurations, the irradiation amount is simulated for voxels of the patient image data. Constraints to be fulfilled by the treatment plan may be set. Configurations of blockings, arc-weights and margins are proposed. Only different combinations of these parameters are proposed while additional possible parameters are neglected. An optimization algorithm is used to minimize an objective function. The best configuration is selected as the treatment plan.

公开(公告)号：US12194312B2

公开(公告)日：2025-01-14

申请号：US17252052

申请日：2020-07-16

Applicant: Brainlab AG

Inventor： Cornelis Kamerling ,  Stefan Schell

IPC: A61N5/10 ,  G16H10/60 ,  G16H20/40 ,  G16H40/40 ,  G16H40/63 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  G16H70/20

Abstract: The present application provides an initial, or first, packed arc setup to be compared with predefined arc setup constraints. These predefined arc setup constraints constrain at least one or more of the number of patient table angles per target volume, the number of times the gantry moves along one arc per table angle, the sum of gantry span per metastasis over all arcs, and the minimum table span. Based on the result of the comparison between the packed first arc setup with the predefined arc setup constraints, a second arc setup is automatically suggested. The automatically suggested second arc setup may then be compared with the first arc setup by calculating a score for both setups. Several iterations of such a method can be carried out based on the comparison between an arc setup and the following, subsequent arc setup in the iteration.

公开(公告)号：US20250135227A1

公开(公告)日：2025-05-01

申请号：US18693481

申请日：2022-12-21

Applicant: Brainlab AG

Inventor： Cornelis Kamerling ,  Stefan SCHELL

IPC: A61N5/10

Abstract: According to the present invention, the method presented herein may determine, which lesions of a patient need modulation, and which not. In an optional step an arc setup optimization is performed for creating the RT treatment plan. Moreover, a conformal shape optimization is performed, preferably for all lesions of the patient. Furthermore, a VMAT optimization is performed with the restriction that conformal the shapes determined before must stay conformal during the VMAT optimization for subset of lesions. In this way, the benefits of conformal arcs and modulated arcs are combined by generation of treatment plans using hybrid arcs. This method allows that each arc can contain both conformal and modulated apertures.

公开(公告)号：US20240312597A1

公开(公告)日：2024-09-19

申请号：US18027029

申请日：2022-05-13

Applicant: Brainlab AG

Inventor： Mattia Donzelli ,  Cornelis Kamerling

IPC: G16H20/40 ,  A61N5/10

CPC classification number: G16H20/40 ,  A61N5/1031

Abstract: The present invention provides a computer-implemented method for determining a treatment plan for a radiotherapy treatment including a dose distribution, the method comprising the steps of determining a transition region target thickness of a transition region comprised in a low dose target volume and adjacent to a high dose target volume. The method further comprises creating shells and determining, for each of the shells, a shell-specific upper dose constraint. The method further comprises generating, by means of an optimization algorithm, a treatment plan, the optimization algorithm constrained by a predetermined lower dose constraint in the high dose target volume, an upper dose constraint in the low dose target volume, and the respective shell-specific upper dose constraint.

公开(公告)号：US11583699B2

公开(公告)日：2023-02-21

申请号：US16963524

申请日：2019-09-27

Applicant: Brainlab AG

Inventor： Cornelis Kamerling ,  Stefan Schell

IPC: A61N5/10 ,  G16H20/40 ,  G16H10/60 ,  G16H50/30 ,  G16H50/70 ,  G16H50/20 ,  G16H40/40 ,  G16H40/63 ,  G16H70/20

Abstract: The present application provides an initial, or first, packed arc setup to be compared with predefined arc setup constraints. These predefined arc setup constraints constrain at least one or more of the number of patient table angles per target volume, the number of times the gantry moves along one arc per table angle, the sum of gantry span per metastasis over all arcs, and the minimum table span. Based on the result of the comparison between the first packed arc setup with the predefined arc setup constraints, a second arc setup is automatically suggested. The automatically suggested second arc setup may then be compared with the first arc setup by calculating a score for both setups. Several iterations of such a method can be carried out based on the comparison between an arc setup and the following, subsequent arc setup in the iteration.