公开(公告)号：US11339179B2

公开(公告)日：2022-05-24

申请号：US16772888

申请日：2018-12-11

申请人： CE Pharm Co., Ltd.

发明人： Dawei Ma ,  Weiming He ,  Zhigao Zhang

IPC分类号： C07D515/22

摘要： The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.

公开(公告)号：US10759765B2

公开(公告)日：2020-09-01

申请号：US16093688

申请日：2017-04-14

申请人： CE Pharm CO., LTD.

发明人： Dawei Ma ,  Wei Zhou ,  Mengyang Fan ,  Haibo Wu ,  Junli Yin ,  Xi Jiang ,  Yuntong Zhai ,  Songtao Niu

IPC分类号： C07D241/02 ,  B01J31/22 ,  C07C231/02 ,  C07C233/00 ,  C07D207/32 ,  C07D209/08 ,  C07D209/12 ,  C07D213/06 ,  C07D235/08 ,  C07D239/02 ,  C07D277/02 ,  C07D277/62 ,  C07D307/02 ,  C07D307/78 ,  C07C209/60

摘要： Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

公开(公告)号：US20210163500A1

公开(公告)日：2021-06-03

申请号：US16772888

申请日：2018-12-11

申请人： CE Pharm Co., Ltd.

发明人： Dawei Ma ,  Weiming He ,  Zhigao Zhang

IPC分类号： C07D515/22

摘要： The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.