公开(公告)号：US20170369451A1

公开(公告)日：2017-12-28

申请号：US15537954

申请日：2015-12-23

Applicant: CEPHALON, INC.

Inventor： Shawn P. ALLWEIN ,  Roger P. BAKALE ,  Dale R. MOWREY ,  Daniel E. PETRILLO ,  Sander KLUWER

IPC: C07D241/04 ,  A61K31/495

CPC classification number: C07D241/04 ,  A61K31/495 ,  C07D295/135 ,  C07D403/12

Abstract: The present disclosure is directed to improved methods useful for the preparation of, for example, 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5Hbenzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methyl-benzamide (CEP-37440).