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公开(公告)号:US20230025843A1
公开(公告)日:2023-01-26
申请号:US17780331
申请日:2020-11-25
发明人: Pilar SÁNCHEZ TESTILLANO , Ana MARTINEZ GIL , Carmen GIL AYUSO-GONTAN , Eduardo BERENGUER PEINADO , Elena CARNEROS GARCÍA , Yolanda PÉREZ PÉREZ
摘要: The present invention relates to the use of mammal kinase inhibitors, preferably human kinase inhibitors, to promote the induction of in vitro embryogenesis, a strategy never used in plants systems before. The results obtained indicated that these inhibitors have beneficial effects in both crop and forest plants in in vitro systems of microspore and somatic embryogenesis.
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2.
公开(公告)号:US20210346388A1
公开(公告)日:2021-11-11
申请号:US17277921
申请日:2019-09-23
发明人: Ana MARTINEZ GIL , Carmen GIL AYUSO-GONTAN , Angeles MARTIN REQUERO , Elisa ROJAS PRATS , Loreto MARTINEZ-GONZALEZ
IPC分类号: A61K31/52
摘要: The present invention relates to the use of a series of purine derivatives having the following general formula: (I) and which are capable of inhibiting CDC7 kinase activity and, therefore, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, which involve hyperphosphorylation of TDP-43 and the subsequent formation of clusters, induced by CDC7.
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