公开(公告)号：US20190201443A1

公开(公告)日：2019-07-04

申请号：US16122562

申请日：2018-09-05

Applicant: California Institute of Technology

Inventor： Alok V Joglekar ,  Michael T Leonard ,  Michael T Bethune ,  David Baltimore

IPC: A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61P37/00

CPC classification number: A61K35/17 ,  A61K48/00 ,  A61P37/00 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70539 ,  C07K2319/03 ,  C07K2319/70 ,  C12N5/0636 ,  C40B40/02 ,  G01N33/566 ,  G01N33/68 ,  G01N2333/7051

Abstract: Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more antigen presenting domains comprise a binding fragment of a major histocompatibility complex (MHC) molecule. Various immunological functions of the SABRs are also described.

公开(公告)号：US12221465B2

公开(公告)日：2025-02-11

申请号：US16122562

申请日：2018-09-05

Applicant: California Institute of Technology

Inventor： Alok V Joglekar ,  Michael T Leonard ,  Michael T Bethune ,  David Baltimore

IPC: C07K14/705 ,  A61K39/00 ,  A61P37/00 ,  C07K14/725 ,  C07K14/74 ,  C12N5/0783 ,  C40B40/02 ,  G01N33/566 ,  G01N33/68 ,  A61K38/00

Abstract: Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more antigen presenting domains comprise a binding fragment of a major histocompatibility complex (MHC) molecule. Various immunological functions of the SABRs are also described.