Benzaepinones as sodium channel blockers
    4.
    发明授权
    Benzaepinones as sodium channel blockers 失效
    Benzaepinones作为钠通道阻滞剂

    公开(公告)号:US07888345B2

    公开(公告)日:2011-02-15

    申请号:US12308209

    申请日:2007-06-05

    摘要: Benzazepinone compounds represented by Formula (I), or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, urinary incontinence, pruritis, itchiness, allergic dermatitis, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

    摘要翻译: 由式(I)表示的苯并氮杂酮化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的症状的方法,包括例如急性疼痛,慢性疼痛,内脏痛,炎性疼痛,神经性疼痛,癫痫,肠易激综合征,尿失禁,瘙痒,瘙痒,过敏性皮炎 抑郁,焦虑,多发性硬化和双相性精神障碍,包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。