专利检索 ap:("Centro De Inmunología Molecular") AND inv:"Daniel Enrique AMARO GONZÁLEZ" 第 1 页

1.

发明申请
Human Recombinant Hyposialylated Erythropoietin, Methods of Purification and Therapeutic Uses Thereof 有权

公开(公告)号：US20220305084A1

公开(公告)日：2022-09-29

申请号：US17640133

申请日：2020-02-19

申请人： Centro De Inmunología Molecular

发明人： Teresita de Jesus RODRÍGUEZ OBAYA , Daniel Enrique AMARO GONZÁLEZ , Judey Aymed GARCÍA ARTALEJO , Iliana Maria SOSA TESTÉ , Yanara SARMIENTO CONDE , Lourdes HERNÁNDEZ DE LA ROSA , Dayli DÍAZ GOIRE , Estela GIMÉNEZ LÓPEZ

IPC分类号： A61K38/18 , A61K47/38 , A61K47/22 , A61K47/18 , A61P25/28

摘要： The present invention relates to the fields of Biotechnology and Medicine and describes a pharmaceutical composition of recombinant human erythropoietin which is characterized by having a microheterogeneity of fucosylated N-glycans formed by bi, tri and tetra-antennary structures with mono and bi-sialylated sialic acid residues that represent 40-60% of the total glycans, trisialylated ones that represent 40-43% of the total glycans and tetrasialylated ones that represent 10-13% of the total glycans. This glycosylation pattern confers properties to said composition that allow for its use in disorders of the nervous system. The method of obtaining the pharmaceutical composition described herein is also described.