公开(公告)号：US20130345161A1

公开(公告)日：2013-12-26

申请号：US13690891

申请日：2012-11-30

申请人： Charles M. Perou ,  Philip S. Bernard ,  Torsten O. Nielsen ,  Matthew J. Ellis ,  Joel S. Parker ,  Miguel Martin ,  Eva Carrasco ,  Rosalia Caballero

发明人： Charles M. Perou ,  Philip S. Bernard ,  Torsten O. Nielsen ,  Matthew J. Ellis ,  Joel S. Parker ,  Miguel Martin ,  Eva Carrasco ,  Rosalia Caballero

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane derivative. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including a taxane or a taxane derivative and administering the therapy in subjects when it is found that a taxane or a taxane derivative is likely to be effective.

摘要翻译： 本申请描述了筛选乳腺癌患者的方法，以确定乳腺癌是否对包括紫杉烷或紫杉烷衍生物在内的乳腺癌治疗有反应。 本申请还描述了通过对治疗患有乳腺癌的受试者的方法进行筛选，以便通过包括紫杉烷或紫杉烷衍生物在内的治疗癌症的有效性的可能性进行筛选，并且当发现紫杉烷或紫杉烷 衍生产品很可能有效。

公开(公告)号：US09181588B2

公开(公告)日：2015-11-10

申请号：US13690891

申请日：2012-11-30

申请人： Charles M. Perou ,  Philip S. Bernard ,  Torsten O. Nielsen ,  Matthew J. Ellis ,  Joel S. Parker ,  Miguel Martin ,  Eva Carrasco ,  Rosalia Caballero

发明人： Charles M. Perou ,  Philip S. Bernard ,  Torsten O. Nielsen ,  Matthew J. Ellis ,  Joel S. Parker ,  Miguel Martin ,  Eva Carrasco ,  Rosalia Caballero

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The application describes methods for screening subjects with breast cancer to determine if the breast cancer will be responsive to a breast cancer therapy including a taxane or a taxane derivative. The application also describes methods for treating subjects with breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including a taxane or a taxane derivative and administering the therapy in subjects when it is found that a taxane or a taxane derivative is likely to be effective.

摘要翻译： 本申请描述了筛选乳腺癌患者的方法，以确定乳腺癌是否对包括紫杉烷或紫杉烷衍生物在内的乳腺癌治疗有反应。 本申请还描述了通过对治疗患有乳腺癌的受试者的方法进行筛选，以便通过包括紫杉烷或紫杉烷衍生物在内的治疗癌症的有效性的可能性进行筛选，并且当发现紫杉烷或紫杉烷 衍生产品很可能有效。