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公开(公告)号：US20210128615A1
公开(公告)日：2021-05-06
申请号：US16757198
申请日：2018-10-18
发明人： Winfried Wels , Anja Waldmann , Congcong Zhang , Manuel Kaulich
IPC分类号： A61K35/17 , C12N5/0783 , C07K16/24 , C12N15/113 , C12N15/11
摘要： The present invention pertains to methods and compounds useful in a therapy involving the administration of immune cells to a patient. The method of the invention involves the modification of cells of the immune system with agonists or antagonists of immune regulators such as Interleukin-10 (IL-10) or IL-6, in order to enhance and improve the immunological potential of the immune cells for therapy. Cells modified according to the method of the invention can be administered to a patient to support a treatment of proliferative diseases such as cancer or autoimmune disorders.
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公开(公告)号：US12023353B2
公开(公告)日：2024-07-02
申请号：US16757198
申请日：2018-10-18
发明人： Winfried Wels , Anja Waldmann , Congcong Zhang , Manuel Kaulich
IPC分类号： A61K35/17 , C07K16/24 , C12N5/0783 , C12N15/11 , C12N15/113
CPC分类号： A61K35/17 , C07K16/244 , C07K16/248 , C12N5/0646 , C12N15/11 , C12N15/1136 , C07K2317/76 , C12N2310/14 , C12N2310/20 , C12N2501/2312 , C12N2501/2315
摘要： The present invention pertains to methods and compounds useful in a therapy involving the administration of immune cells to a patient. The method of the invention involves the modification of cells of the immune system with agonists or antagonists of immune regulators such as Interleukin-10 (IL-10) or IL-6, in order to enhance and improve the immunological potential of the immune cells for therapy. Cells modified according to the method of the invention can be administered to a patient to support a treatment of proliferative diseases such as cancer or autoimmune disorders.
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