公开(公告)号：US20150148403A1

公开(公告)日：2015-05-28

申请号：US14405085

申请日：2013-05-31

Applicant: Chi-Ming LIANG ,  ACADEMIA SINICA

Inventor： Hsiu-Ming Shih ,  Wei-Chih Yang

IPC: C12Q1/68 ,  G01N33/50 ,  C12N15/113

CPC classification number: C12Q1/6897 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q2600/136 ,  G01N33/5008 ,  G01N2333/948 ,  G01N2500/10

Abstract: Method of regulating the stability and/or the level of the fusion protein PLZF/RARA are disclosed. Also disclosed are methods for identifying an agent as a regulator of the stability and/or the level of the fusion protein PLZF/RARA. Methods for identifying a therapeutic agent for treating PLZF/RARA-associated acute promyelocytic leukemia (APL) is also disclosed.

Abstract translation: 公开了调节融合蛋白PLZF / RARA的稳定性和/或水平的方法。 还公开了用于鉴定作为融合蛋白PLZF / RARA的稳定性和/或水平的调节剂的试剂的方法。 还公开了用于鉴定治疗PLZF / RARA相关急性早幼粒细胞白血病（APL）的治疗剂的方法。