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公开(公告)号:US6143744A
公开(公告)日:2000-11-07
申请号:US369501
申请日:1999-08-05
申请人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号: A61K20060101 , C07C20060101 , C07C307/06 , C07D20060101 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , C07D491/048 , A61K31/16 , C07C259/06
CPC分类号: C07D211/36 , C07C307/06 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12
摘要: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译: 本发明涉及作为金属蛋白酶抑制剂的式(I)的磺酰胺,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US06376506B1
公开(公告)日:2002-04-23
申请号:US09469677
申请日:1999-12-22
申请人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号: A61K31435
CPC分类号: C07D295/26 , C07C307/06 , C07D211/36 , C07D213/74 , C07D401/04 , C07D401/12
摘要: This invention relates to sulfamides of formula (I) that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译: 本发明涉及作为金属蛋白酶抑制剂的式(I)的磺酰胺,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US5998412A
公开(公告)日:1999-12-07
申请号:US9951
申请日:1998-01-21
申请人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号: A61K20060101 , C07C20060101 , C07C307/06 , C07D20060101 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , C07D491/048 , A61K31/435 , A61K31/495 , C07D495/04
CPC分类号: C07D211/36 , C07C307/06 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12
摘要: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
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公开(公告)号:US6130220A
公开(公告)日:2000-10-10
申请号:US369677
申请日:1999-08-05
申请人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
发明人: Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Jian Jeffrey Chen , Robert Than Hendricks , Michael Joseph Melnick , Keith Adrian Murray Walker
IPC分类号: C07C307/06 , C07D211/36 , C07D213/74 , C07D295/26 , C07D401/04 , C07D401/12 , A61K31/495 , A01N43/42 , C07D279/10 , C07D471/00 , C07D471/02
CPC分类号: C07D295/26 , C07C307/06 , C07D211/36 , C07D213/74 , C07D401/04 , C07D401/12
摘要: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
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公开(公告)号:US5932595A
公开(公告)日:1999-08-03
申请号:US769049
申请日:1996-12-18
申请人: Steven Lee Bender , Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Lawrence Emerson Fisher , Robert Than Hendricks , Keshab Sarma
发明人: Steven Lee Bender , Chris Allen Broka , Jeffrey Allen Campbell , Arlindo Lucas Castelhano , Lawrence Emerson Fisher , Robert Than Hendricks , Keshab Sarma
IPC分类号: C07D333/34 , A61K31/00 , A61K31/10 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61P1/00 , A61P1/02 , A61P3/00 , A61P5/00 , A61P19/00 , A61P19/10 , A61P27/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C315/02 , C07C317/44 , C07C323/51 , C07D211/54 , C07D213/64 , C07D213/643 , C07D307/14 , C07D309/08 , C07D335/02 , C07D401/04 , C07D401/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , A01N43/40 , A01N37/10 , A01N43/36 , C07C233/00 , C07D207/00 , C07D211/08 , C07D333/32 , C07C415/00
CPC分类号: C07D213/643 , C07D211/54 , C07D309/08 , C07D401/06 , C07D407/12 , C07D409/12 , C07D413/12 , Y10S514/825 , Y10S514/885 , Y10S514/90 , Y10S514/903
摘要: The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.
摘要翻译: 本发明涉及式I化合物:基质金属蛋白酶抑制剂,含有它们的药物组合物,其使用方法和制备这些化合物的方法。
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公开(公告)号:US20110070190A1
公开(公告)日:2011-03-24
申请号:US12890218
申请日:2010-09-24
IPC分类号: A61K31/4365 , C07D495/04 , A61K31/437 , A61K39/00 , A61K38/21 , A61K38/20 , A61K38/19 , A61P31/14 , C12N5/02
CPC分类号: C07D495/04
摘要: The invention discloses 1-N-substituted-6-(hetero)aryl-1H-thieno[3,2-d]pyrimidin-4-one derivatives of formula wherein R1, R2, R3 and R4 are as defined herein that inhibit Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译: 本发明公开了下式的1-N-取代-6-(杂)芳基-1H-噻吩并[3,2-d]嘧啶-4-酮衍生物其中R 1,R 2,R 3和R 4如本文所定义,其抑制丙型肝炎 病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号:US20110288097A1
公开(公告)日:2011-11-24
申请号:US13110053
申请日:2011-05-18
申请人: Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
发明人: Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
IPC分类号: A61K31/4985 , A61P37/02 , A61P3/10 , A61P17/02 , A61P17/06 , A61P25/28 , A61P35/02 , A61P11/06 , A61P35/00 , C07D471/04 , A61P1/00
CPC分类号: C07D487/04
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途,其中变量Q和R 1和R 2如本文所述定义,其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号:US20110230414A1
公开(公告)日:2011-09-22
申请号:US13039433
申请日:2011-03-03
申请人: Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
发明人: Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen M. Lynch , Timothy D. Owens , Michael Soth
IPC分类号: A61K38/00 , C07D487/04 , A61K31/4985 , A61P29/00 , A61P35/00 , A61P9/00 , A61P3/10 , A61P19/02 , A61P37/06 , A61P11/06 , A61P1/04 , A61P5/02 , A61P25/28
CPC分类号: C07D487/04
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q, R2, R3, and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途,其中变量Q,R2,R3和Y如本文所述定义,其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病 。
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公开(公告)号:US08329699B2
公开(公告)日:2012-12-11
申请号:US13110053
申请日:2011-05-18
申请人: Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
发明人: Robert Than Hendricks , Johannes Hermann , Rama Kondru , Yan Lou , Stephen Lynch , Timothy D. Owens , Michael Soth , Calvin Yee
IPC分类号: A61K31/495
CPC分类号: C07D487/04
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途,其中变量Q和R 1和R 2如本文所述定义,其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号:US08119636B2
公开(公告)日:2012-02-21
申请号:US12378837
申请日:2009-02-20
申请人: Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , David Bernard Smith
发明人: Daisy Joe DuBois , Todd Richard Elworthy , Robert Than Hendricks , Johannes Cornelius Hermann , Rama K. Kondru , Yan Lou , Timothy D. Owens , David Bernard Smith
IPC分类号: A61K31/495
CPC分类号: C07D487/04
摘要: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译: 本发明涉及式I的新型吡咯并吡嗪衍生物的用途,其中变量Q和R如本文所述定义,其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。
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