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公开(公告)号：US09527881B2
公开(公告)日：2016-12-27
申请号：US12918036
申请日：2009-02-26
申请人： Christopher Macnevin , Donald G. Stein , Dennis C. Liotta , Iqbal Sayeed , David B. Guthrie , Mark A. Lockwood , Michael G. Natchus
发明人： Christopher Macnevin , Donald G. Stein , Dennis C. Liotta , Iqbal Sayeed , David B. Guthrie , Mark A. Lockwood , Michael G. Natchus
CPC分类号： A61K31/573 , C07J9/00
摘要： Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.
摘要翻译： 提供的是在类固醇环系统的C3和/或C20位置上被极性取代基官能化的类固醇类似物，其具有改善的水溶性。 还提供了包含类固醇类似物的药物组合物和使用新型类固醇类似物在中枢神经系统损伤后治疗和预防患者神经变性的方法。
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公开(公告)号：US20110263553A1
公开(公告)日：2011-10-27
申请号：US12918036
申请日：2009-02-26
申请人： Christopher Macnevin , Donald G. Stein , Dennis C. Liotta , Iqbal Sayeed , David B. Guthrie , Mark A. Lockwood , Michael G. Natchus
发明人： Christopher Macnevin , Donald G. Stein , Dennis C. Liotta , Iqbal Sayeed , David B. Guthrie , Mark A. Lockwood , Michael G. Natchus
CPC分类号： A61K31/573 , C07J9/00
摘要： Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the treatment and prevention of neurodegeneration in a patient following injury to the central nervous system.
摘要翻译： 提供的是在类固醇环系统的C3和/或C20位置上被极性取代基官能化的类固醇类似物，其具有改善的水溶性。 还提供了包含类固醇类似物的药物组合物和使用新型类固醇类似物在中枢神经系统损伤后治疗和预防患者神经变性的方法。
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3.发明申请METHOD FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CANCERS AND COMPOSITIONS RELATED THERETO 有权治疗中枢神经系统癌症及其相关组合物的方法公开(公告)号：US20130310350A1
公开(公告)日：2013-11-21
申请号：US13783706
申请日：2013-03-04
申请人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
发明人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
IPC分类号： A61K31/57
CPC分类号： A61K31/57 , A61K45/06 , A61K2300/00
摘要： Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is provided. The treatment offers a reduced toxicity as compared to the currently available chemotherapeutic agents. The progesterone may be administered alone or in combination with, or in conjunction with other therapeutic agents.
摘要翻译： 本文公开的化合物，通常是孕酮或其类似物或衍生物在治疗中枢神经系统癌症，特别是神经母细胞瘤和成胶质细胞瘤中的用途。 与目前可用的化学治疗剂相比，该治疗提供了降低的毒性。 孕酮可以单独施用或与其它治疗剂组合或联合施用。
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4.发明申请METHOD FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CANCERS AND COMPOSITIONS RELATED THERETO 审中-公开治疗中枢神经系统癌症及其相关组合物的方法公开(公告)号：US20140296195A1
公开(公告)日：2014-10-02
申请号：US14302038
申请日：2014-06-11
申请人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
发明人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
CPC分类号： A61K31/57 , A61K45/06 , A61K2300/00
摘要： Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is provided. The treatment offers a reduced toxicity as compared to the currently available chemotherapeutic agents. The progesterone may be administered alone or in combination with, or in conjunction with other therapeutic agents.
摘要翻译： 本文公开的化合物，通常是孕酮或其类似物或衍生物在治疗中枢神经系统癌症，特别是神经母细胞瘤和成胶质细胞瘤中的用途。 与目前可用的化学治疗剂相比，该治疗提供了降低的毒性。 孕酮可以单独施用或与其它治疗剂组合或联合施用。
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5.发明申请METHOD FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CANCERS AND COMPOSITIONS RELATED THERETO 有权治疗中枢神经系统癌症及其相关组合物的方法公开(公告)号：US20120058978A1
公开(公告)日：2012-03-08
申请号：US13222021
申请日：2011-08-31
申请人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
发明人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
CPC分类号： A61K31/57 , A61K45/06 , A61K2300/00
摘要： Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is provided. The treatment offers a reduced toxicity as compared to the currently available chemotherapeutic agents. The progesterone may be administered alone or in combination with, or in conjunction with other therapeutic agents.
摘要翻译： 本文公开的化合物，通常是孕酮或其类似物或衍生物在治疗中枢神经系统癌症，特别是神经母细胞瘤和成胶质细胞瘤中的用途。 与目前可用的化学治疗剂相比，该治疗提供了降低的毒性。 孕酮可以单独施用或与其它治疗剂组合或联合施用。
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公开(公告)号：US20140221480A1
公开(公告)日：2014-08-07
申请号：US14173942
申请日：2014-02-06
申请人： Fang Hua , Donald G. Stein , Iqbal Sayeed
发明人： Fang Hua , Donald G. Stein , Iqbal Sayeed
IPC分类号： A61K31/24
CPC分类号： A61K31/18
摘要： This disclosure relates to methods of managing brain injury such as inflammation due to trauma induced brain injury and ischemic stroke by administering resatorvid or derivative there of a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating cerebral ischemia comprising administering an effective amount of resatorvid to a subject in need thereof. In certain embodiments, the effective amount is 3 mg/kg. In certain embodiments, resatorvid is administered by injection.
摘要翻译： 本公开涉及通过在有需要的受试者施用resatorvid或衍生物来管理脑损伤（例如由于创伤诱导的脑损伤和缺血性中风引起的炎症）的方法。 在某些实施方案中，本公开涉及治疗脑缺血的方法，包括向有需要的受试者施用有效量的resatorvid。 在某些实施方案中，有效量为3mg / kg。 在某些实施方案中，resatorvid通过注射施用。
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7.发明授权Method for the treatment of central nervous system cancers and compositions related thereto 有权治疗中枢神经系统癌症及其相关组合物的方法公开(公告)号：US08778915B2
公开(公告)日：2014-07-15
申请号：US13783706
申请日：2013-03-04
申请人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
发明人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
IPC分类号： A61K31/56
CPC分类号： A61K31/57 , A61K45/06 , A61K2300/00
摘要： Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is provided. The treatment offers a reduced toxicity as compared to the currently available chemotherapeutic agents. The progesterone may be administered alone or in combination with, or in conjunction with other therapeutic agents.
摘要翻译： 本文公开的化合物，通常是孕酮或其类似物或衍生物在治疗中枢神经系统癌症，特别是神经母细胞瘤和成胶质细胞瘤中的用途。 与目前可用的化学治疗剂相比，该治疗提供了降低的毒性。 孕酮可以单独施用或与其它治疗剂组合或联合施用。
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8.发明授权Method for the treatment of central nervous system cancers and compositions related thereto 有权治疗中枢神经系统癌症及其相关组合物的方法公开(公告)号：US08435972B2
公开(公告)日：2013-05-07
申请号：US13222021
申请日：2011-08-31
申请人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
发明人： Donald G. Stein , Iqbal Sayeed , Fahim Atif
IPC分类号： A61K31/56
CPC分类号： A61K31/57 , A61K45/06 , A61K2300/00
摘要： Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is provided. The treatment offers a reduced toxicity as compared to the currently available chemotherapeutic agents. The progesterone may be administered alone or in combination with, or in conjunction with other therapeutic agents.
摘要翻译： 本文公开的化合物，通常是孕酮或其类似物或衍生物在治疗中枢神经系统癌症，特别是神经母细胞瘤和成胶质细胞瘤中的用途。 与目前可用的化学治疗剂相比，该治疗提供了降低的毒性。 孕酮可以单独施用或与其它治疗剂组合或联合施用。
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