公开(公告)号：US4889524A

公开(公告)日：1989-12-26

申请号：US093366

申请日：1987-09-04

申请人： Claude Fell ,  Etienne Pages ,  Dominique Uhlmann

发明人： Claude Fell ,  Etienne Pages ,  Dominique Uhlmann

IPC分类号： A61M1/02 ,  A61M1/36 ,  B04B5/00 ,  B04B5/04 ,  B04B7/00 ,  B04B7/08 ,  B04B9/00 ,  G01L9/00 ,  G01L9/14

CPC分类号： G01L9/14 ,  A61M1/3693 ,  A61M1/3696 ,  B04B5/0442 ,  B04B7/08 ,  G01L9/0004 ,  B04B2005/0464

摘要： A portable centrifuge apparatus for use with a centrifuge bowl having a seamless, unitary blow molded bowl body for the separation of blood into less dense and more dense components. A light weight, hand-held cabinet houses the centrifuge, and auxiliary equipment such as blood pumps, control instrumentation, and a sensor for measuring fluid pressure in a disposable chamber used for filtering blood.

摘要翻译： 一种与离心机碗一起使用的便携式离心机，其具有无缝的，单一的吹塑成型的碗体，用于将血液分离成更致密和更致密的组分。 重量轻的手提式办公室安装离心机，以及辅助设备，如血液泵，控制仪器和用于测量用于过滤血液的一次性室内的流体压力的传感器。

公开(公告)号：US20090259162A1

公开(公告)日：2009-10-15

申请号：US12102486

申请日：2008-04-14

申请人： Toshiyasu Ohashi ,  Etienne Pages ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

发明人： Toshiyasu Ohashi ,  Etienne Pages ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

IPC分类号： A61M1/38

CPC分类号： A61M1/0263 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/0259 ,  A61M1/0272 ,  A61M1/029 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/382 ,  A61M2202/0413 ,  A61M2202/0427

摘要： A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.

摘要翻译： 一种用于收集可能悬浮在来自供体的合成溶液中的血浆还原血小板的方法和装置。 从供体抽出全血并引入分离室。 使用例如喘振（具有抗凝血浆或合成溶液）或推进方法将血小板从分离室提取到容器中。 分离室中的剩余血液成分返回给供体。 将全血全血引入分离室，将分离室中的血小板从容器中取出并将其中的剩余组分重新送回供体的步骤。 将容器中的隔离血小板重新引入分离室，从而提取血浆减少的血小板产物。

公开(公告)号：US08808978B2

公开(公告)日：2014-08-19

申请号：US13883518

申请日：2010-11-15

申请人： Etienne Pagès ,  Dominique Uhlmann ,  Matthew Murphy

发明人： Etienne Pagès ,  Dominique Uhlmann ,  Matthew Murphy

IPC分类号： C12N5/078

CPC分类号： B04B15/06 ,  A61M1/0281 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  B04B11/04 ,  B04B13/00 ,  C12N5/0644

摘要： A method for washing platelets includes introducing anticoagulant into a platelet product container, drawing re-anticoagulated platelet product from the platelet product container, and introducing it into a centrifuge bowl. The centrifuge bowl separates the platelets from the supernatant in which they are suspended. The method then washes the platelets by introducing wash solution into the centrifuge bowl. As the wash solution is introduced into the bowl, it displaces the supernatant from the bowl and into a waste container. The method then introduces platelet additive solution into the centrifuge bowl, which displaces the wash solution from the centrifuge bowl and into the waste container and further wash the platelets. The method then repeatedly accelerates and decelerates the centrifuge bowl to resuspend the platelets in the platelet additive solution.

摘要翻译： 洗涤血小板的方法包括将抗凝血剂引入血小板产品容器中，从血小板产品容器中抽出抗凝血小板产物，并将其引入离心机碗中。 离心机碗将血小板与悬浮的上清液分离。 该方法然后通过将洗涤溶液引入离心机碗中洗涤血小板。 当洗涤溶液被引入碗中时，它将上清液从碗中移出并进入废物容器。 然后，该方法将血小板添加剂溶液引入离心机碗中，将洗涤溶液从离心机碗排出并进入废液容器中，并进一步洗涤血小板。 该方法然后重复加速和减速离心机碗以使血小板重新悬浮在血小板添加剂溶液中。

公开(公告)号：US20130309652A1

公开(公告)日：2013-11-21

申请号：US13883518

申请日：2010-11-15

申请人： Etienne Pagés ,  Dominique Uhlmann ,  Matthew Murphy

发明人： Etienne Pagés ,  Dominique Uhlmann ,  Matthew Murphy

IPC分类号： C12N5/078

CPC分类号： B04B15/06 ,  A61M1/0281 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  B04B11/04 ,  B04B13/00 ,  C12N5/0644

摘要： A method for washing platelets includes introducing anticoagulant into a platelet product container, drawing re-anticoagulated platelet product from the platelet product container, and introducing it into a centrifuge bowl. The centrifuge bowl separates the platelets from the supernatant in which they are suspended. The method then washes the platelets by introducing wash solution into the centrifuge bowl. As the wash solution is introduced into the bowl, it displaces the supernatant from the bowl and into a waste container. The method then introduces platelet additive solution into the centrifuge bowl, which displaces the wash solution from the centrifuge bowl and into the waste container and further wash the platelets. The method then repeatedly accelerates and decelerates the centrifuge bowl to resuspend the platelets in the platelet additive solution.

摘要翻译： 洗涤血小板的方法包括将抗凝血剂引入血小板产品容器中，从血小板产品容器中抽出抗凝血小板产物，并将其引入离心机碗中。 离心机碗将血小板与悬浮的上清液分离。 该方法然后通过将洗涤溶液引入离心机碗中洗涤血小板。 当洗涤溶液被引入碗中时，它将上清液从碗中移出并进入废物容器。 然后，该方法将血小板添加剂溶液引入离心机碗中，将洗涤溶液从离心机碗排出并进入废液容器中，并进一步洗涤血小板。 该方法然后重复加速和减速离心机碗以使血小板重新悬浮在血小板添加剂溶液中。

公开(公告)号：US08454548B2

公开(公告)日：2013-06-04

申请号：US12102486

申请日：2008-04-14

申请人： Toshiyasu Ohashi ,  Etienne Pagès ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

发明人： Toshiyasu Ohashi ,  Etienne Pagès ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

IPC分类号： A61M37/00 ,  A61M1/36 ,  A61M1/38 ,  B01D36/00

CPC分类号： A61M1/0263 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/0259 ,  A61M1/0272 ,  A61M1/029 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/382 ,  A61M2202/0413 ,  A61M2202/0427

摘要： A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.

摘要翻译： 一种用于收集可能悬浮在来自供体的合成溶液中的血浆还原血小板的方法和装置。 从供体抽出全血并引入分离室。 使用例如喘振（具有抗凝血浆或合成溶液）或推进方法将血小板从分离室提取到容器中。 分离室中的剩余血液成分返回给供体。 将全血全血引入分离室，将分离室中的血小板从容器中取出并将其中的剩余组分重新送回供体的步骤。 将容器中的隔离血小板重新引入分离室，从而提取血浆减少的血小板产物。