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公开(公告)号:US08349839B2
公开(公告)日:2013-01-08
申请号:US12756276
申请日:2010-04-08
申请人: Claudio Sturino , Patrick Deroy , Martin Duplessis , Paul J. Edwards , Anne-Marie Faucher , Teddy Halmos , Clint James , Jean-Eric Lacoste , Eric Malenfant , Joannie Minville , Louis Morency , Sebastien Morin , Martin Tremblay , Christiane Yoakim
发明人: Claudio Sturino , Patrick Deroy , Martin Duplessis , Paul J. Edwards , Anne-Marie Faucher , Teddy Halmos , Clint James , Jean-Eric Lacoste , Eric Malenfant , Joannie Minville , Louis Morency , Sebastien Morin , Martin Tremblay , Christiane Yoakim
IPC分类号: A61K31/501 , A61K31/34 , C07D237/36 , C07D307/92
CPC分类号: C07D491/048 , C07D487/04 , C07D491/147 , C07D513/04 , C07D519/00
摘要: Compounds of formula (I): wherein R1, R2, A1, A2, A3, A4, X and Y are as defined herein, are useful as inhibitors of HIV replication.
摘要翻译: 式(I)化合物:其中R1,R2,A1,A2,A3,A4,X和Y如本文所定义,可用作HIV复制的抑制剂。
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公开(公告)号:US20150011531A1
公开(公告)日:2015-01-08
申请号:US14366421
申请日:2012-12-19
申请人: Claudio Sturino , Pierre Beaulieu , Patrick Deroy , Martin Duplessis , Clint James , Jean-Eric Lacoste , Joannie Minville , Louis Morency , Sébastien Morin , Bruno Simoneau , Martin Tremblay
发明人: Claudio Sturino , Pierre Beaulieu , Patrick Deroy , Martin Duplessis , Clint James , Jean-Eric Lacoste , Joannie Minville , Louis Morency , Sébastien Morin , Bruno Simoneau , Martin Tremblay
IPC分类号: C07D491/147 , A61K45/06 , A61K31/5377 , A61K31/519 , C07D491/048
CPC分类号: C07D491/147 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D491/048
摘要: Compounds of formula (I) and pharmaceutical compositions thereof: wherein A1 A2 and A3 are each independently selected from the group consisting of N and CR3, wherein R1 is an optionally substituted heterocyclyl or an optionally substituted —(C1-6)alkyl-heterocyclyl, R2 is an optionally substituted aryl or an optionally subsisted heteroaryl, R4 is an optionally substituted aryl, an optionally substituted heterocyclyl or an optionally substituted heteroaryl, useful as an inhibitor of HIV replication.
摘要翻译: 式(I)化合物及其药物组合物:其中A1 A2和A3各自独立地选自N和CR 3,其中R 1是任选取代的杂环基或任选取代的 - (C 1-6)烷基 - 杂环基, R 2是任选取代的芳基或任选取代的杂芳基,R 4是任选取代的芳基,任选取代的杂环基或任选取代的杂芳基,其可用作HIV复制的抑制剂。
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公开(公告)号:US20200008481A1
公开(公告)日:2020-01-09
申请号:US16571082
申请日:2019-09-14
申请人: Martin Tremblay
发明人: Martin Tremblay
IPC分类号: A24F47/00
摘要: An electronic vaping device may be designed to enhance or facilitate its use. For example, the electronic vaping device may: allow a capability of the electronic vaping device to provide vapor to be altered (e.g., disabled, reduced, enabled, or increased) in some situations (e.g., to prevent unauthorized vaping by a child, teenager or other individual); be able to communicate with an external communication device (e.g., a smartphone, a computer, etc.) to convey a notification of potential unauthorized use of the electronic vaping device (e.g., by a child, teenager or other unauthorized user); implement a physical deterrent to its unauthorized use; be able to visually convey information (e.g., advertisements, notifications, etc.); and/or be able to capture images and/or sounds (e.g., record pictures and/or video, speech, music, etc.).
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公开(公告)号:US20180289074A1
公开(公告)日:2018-10-11
申请号:US16008009
申请日:2018-06-13
申请人: Martin Tremblay
发明人: Martin Tremblay
IPC分类号: A24F47/00
CPC分类号: A24F47/008
摘要: An electronic vaping device may be designed to enhance or facilitate its use. For example, the electronic vaping device may: allow a capability of the electronic vaping device to provide vapor to be altered (e.g., disabled, reduced, enabled, or increased) in some situations (e.g., to prevent unauthorized vaping by a child, teenager or other individual); be able to communicate with an external communication device (e.g., a smartphone, a computer, etc.) to convey a notification of potential unauthorized use of the electronic vaping device (e.g., by a child, teenager or other unauthorized user); implement a physical deterrent to its unauthorized use; be able to visually convey information (e.g., advertisements, notifications, etc.); and/or be able to capture images and/or sounds (e.g., record pictures and/or video, speech, music, etc.).
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公开(公告)号:US07964590B2
公开(公告)日:2011-06-21
申请号:US12044878
申请日:2008-03-07
IPC分类号: A61K31/55 , C07D491/20
CPC分类号: C07D491/20 , C07D215/06
摘要: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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公开(公告)号:US20080293755A1
公开(公告)日:2008-11-27
申请号:US12044817
申请日:2008-03-07
IPC分类号: C07D491/10 , A61K31/4355 , C07D491/20 , A61P35/00 , A61K31/437
CPC分类号: C07D491/14 , C07D513/14
摘要: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及可用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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公开(公告)号:US20080287420A1
公开(公告)日:2008-11-20
申请号:US12044878
申请日:2008-03-07
IPC分类号: A61K31/4375 , C07D491/147 , A61K31/55 , A61P35/00
CPC分类号: C07D491/20 , C07D215/06
摘要: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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公开(公告)号:US20190258253A1
公开(公告)日:2019-08-22
申请号:US16279778
申请日:2019-02-19
申请人: Martin Tremblay
发明人: Martin Tremblay
摘要: An autonomous vehicle configured to facilitate its use and/or enhance what it and/or occupants can do with it, such as, for example, by: autonomously acting based on events within the autonomous vehicle, including by autonomously rerouting itself, altering a cabin of the autonomous vehicle, notifying a third party external to the autonomous vehicle, stopping (e.g., parking) the autonomous vehicle, altering how the autonomous vehicle drives itself, and/or performing other actions based on what and/or how an occupant is doing, an emergency, or another event occurring in the cabin of the autonomous vehicle; autonomously acting based on interactions with (e.g., gestures of) humans (e.g., police officers, school-crossing guards, traffic guards at roadwork or other temporary traffic control sites, drivers of other vehicles, etc.) external to the autonomous vehicle; autonomously acting based on indicators placed at particular locations (e.g., drive-through establishments, potholes, parking spots, etc.); facilitating acts of occupants in the cabin of the autonomous vehicle, such as acts unrelated to and normally not done while driving, including, for example, sleeping, exercising, working, eating, cooking, and/or any other suitable act; and/or automatically personalizing the autonomous vehicle for an occupant (e.g., a configuration of the cabin, a self-driving mode, a destination and/or a route, etc.).
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公开(公告)号:US08017648B2
公开(公告)日:2011-09-13
申请号:US11965675
申请日:2007-12-27
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供了使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20100286180A1
公开(公告)日:2010-11-11
申请号:US11965675
申请日:2007-12-27
IPC分类号: A61K31/4355 , A61P35/00 , A61P35/04
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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