公开(公告)号：US20250073169A1

公开(公告)日：2025-03-06

申请号：US18293204

申请日：2022-08-02

Applicant: CORNELL UNIVERSITY

Inventor： Rong YANG ,  Trevor FRANKLIN ,  Danielle STREEVER

IPC: A61K9/16 ,  A61K31/131 ,  C08F212/36 ,  C08F220/28 ,  C08F226/06

Abstract: Provided is a method of synthesizing polymer particles, including: introducing vapor-phase reagents into a reactor having a substrate; forming condensed droplets of the reagents on the substrate; initiating polymerization; and polymerizing the condensed droplets of the reagents, thereby forming polymer particles. Polymer particles are also provided, including those incorporating therapeutic agents.

公开(公告)号：US20220332869A1

公开(公告)日：2022-10-20

申请号：US17454763

申请日：2021-11-12

Applicant: Cornell University

Inventor： Rong YANG ,  Trevor FRANKLIN

IPC: C08F226/06 ,  C08F220/24 ,  C08F212/36 ,  C09D5/16

Abstract: Provided are amphiphilic copolymers that include repeat units of formulas [Z]m and [P]n, wherein Z is a zwitterionic structural unit including at least one pendant heteroaromatic moiety, the heteroaromatic moiety containing a positively charged quaternary nitrogen atom (e.g., a pyridine ring), and wherein at least one negatively charged functional moiety is linked to the heteroaromatic moiety directly or through a linker, wherein the linker, where present, is an optionally substituted alkyl linker; P is a structural unit including a hydrophobic moiety, the hydrophobic moiety being a linear, branched, or cyclic fluorine-substituted C1-C20 moiety; m is an integer that is ≥1; and n is an integer that is ≥1.