公开(公告)号：US20190144469A1

公开(公告)日：2019-05-16

申请号：US16300257

申请日：2017-06-23

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Yuhan ZHOU ,  Jingping QU ,  Yang LIU ,  Yilong ZHAO

IPC: C07F5/02 ,  C07C69/76

Abstract: The present invention relates to a method for preparing difluoroallylboronate and application thereof, and it belongs to a field of compound preparation. A method for preparing difluoroallyl borate ester is using a compound of the formula II and bis (pinacolato) diboron as raw materials in a solvent and in the presence of an iron catalyst and a base according to the following reaction formula, to obtain a compound of the formula I, The method of the present invention directly use an inexpensive, commercially available metal iron salt as a catalyst to provide a convenient, low-cost method for preparing difluoroallyl borate ester, and provide a new and effective approach for the synthesis of γ-aminobutyric acid receptor agonist (III).