公开(公告)号：US20170143744A1

公开(公告)日：2017-05-25

申请号：US15402712

申请日：2017-01-10

申请人： DR. REDDY'S LABORATORIES LIMITED

发明人： Riyaz Ahmed SHAIK ,  Ananya SAHA ,  Svb Janardhan GARIKIPATI ,  Akash CHAURASIYA ,  Bhavesh Vallabhbhai PATEL ,  Harshal BHAGWATWAR ,  Ashok Pillai SUMITRA

IPC分类号： A61K31/664 ,  B01D15/08 ,  A61K47/26 ,  A61K47/44 ,  A61K47/10 ,  A61K9/08

CPC分类号： A61K31/664 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K31/675 ,  A61K47/10 ,  A61K47/26 ,  A61K47/44 ,  B01D15/08

摘要： The present invention relates to stable liquid pharmaceutical formulations of cyclophosphamide comprising cyclophosphamide and at least one pharmaceutically acceptable excipient wherein moisture content of the liquid formulation is less than about 2.0% by weight. The invention further relates to stable liquid formulations of cyclophosphamide prepared by a process comprising a step of reducing the moisture content from cyclophosphamide or liquid compositions of cyclophosphamide or both. The invention further relate to method of using such stable liquid formulations of cyclophosphamide for parenteral administration either as ready-to-use or ready-to-dilute for treating various cancer disorders.