公开(公告)号：US20230074669A1

公开(公告)日：2023-03-09

申请号：US17535369

申请日：2021-11-24

申请人： Daiichi Sankyo Company, Limited

发明人： Kenji Yoshikawa ,  Noriyasu Haginoya ,  Tomoaki Hamada ,  Ryutaro Kanada ,  Jun Watanabe ,  Yoshiko Kagoshima ,  Eri Tokumaru ,  Kenji Murata ,  Takayuki Baba ,  Mayumi Kitagawa ,  Akiko Kurimoto ,  Masashi Numata ,  Machiko Shiroishi ,  Taeko Shinozaki

IPC分类号： C07D495/04 ,  A61P35/02 ,  A61K45/06

摘要： The present invention provides a compound or a pharmaceutically acceptable salt thereof having an inhibitory action on the interaction between menin and an MLL protein. The compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. wherein, in the formula (1), the dotted circle, R1, R2, R3, R4, R5, R6, R7, R8, Ring Q1, W, m and n are each as defined in the description.

公开(公告)号：US11236106B2

公开(公告)日：2022-02-01

申请号：US17243360

申请日：2021-04-28

申请人： Daiichi Sankyo Company, Limited

发明人： Kenji Yoshikawa ,  Noriyasu Haginoya ,  Tomoaki Hamada ,  Ryutaro Kanada ,  Jun Watanabe ,  Yoshiko Kagoshima ,  Eri Tokumaru ,  Kenji Murata ,  Takayuki Baba ,  Mayumi Kitagawa ,  Akiko Kurimoto ,  Masashi Numata ,  Machiko Shiroishi ,  Taeko Shinozaki

IPC分类号： C07D495/04 ,  A61P35/02 ,  A61K45/06

摘要： The present invention provides a compound or a pharmaceutically acceptable salt thereof having an inhibitory action on the interaction between menin and an MLL protein. The compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. wherein, in the formula (1), the dotted circle, R1, R2, R3, R4, R5, R6, R7, R8, Ring Q1, W, m and n are each as defined in the description.

公开(公告)号：US20210269454A1

公开(公告)日：2021-09-02

申请号：US17243360

申请日：2021-04-28

申请人： Daiichi Sankyo Company, Limited

发明人： Kenji Yoshikawa ,  Noriyasu Haginoya ,  Tomoaki Hamada ,  Ryutaro Kanada ,  Jun Watanabe ,  Yoshiko Kagoshima ,  Eri Tokumaru ,  Kenji Murata ,  Takayuki Baba ,  Mayumi Kitagawa ,  Akiko Kurimoto ,  Masashi Numata ,  Machiko Shiroishi ,  Taeko Shinozaki

IPC分类号： C07D495/04 ,  A61K45/06 ,  A61P35/02

摘要： The present invention provides a compound or a pharmaceutically acceptable salt thereof having an inhibitory action on the interaction between menin and an MLL protein. The compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. wherein, in the formula (1), the dotted circle, R1, R2, R3, R4, R5, R6, R7, R8, Ring Q1, W, m and n are each as defined in the description.

公开(公告)号：US20230030720A1

公开(公告)日：2023-02-02

申请号：US17289710

申请日：2019-12-05

申请人： Daiichi Sankyo Company, Limited

发明人： Kenji Yoshikawa ,  Noriyasu Haginoya ,  Tomoaki Hamada ,  Ryutaro Kanada ,  Jun Watanabe ,  Yoshiko Kagoshima ,  Eri Tokumaru ,  Kenji Murata ,  Takayuki Baba ,  Mayumi Kitagawa ,  Akiko Kurimoto ,  Masashi Numata ,  Machiko Shiroishi ,  Taeko Shinozaki

IPC分类号： C07D495/04 ,  C07D519/00 ,  C07D403/12 ,  C07D403/14 ,  A61K45/06

摘要： The present invention provides a compound or a pharmaceutically acceptable salt thereof having an inhibitory action on the interaction between menin and an MLL protein. The compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. wherein, in the formula (1), the dotted circle, R1, R2, R3, R4, R5, R6, R7, R8, Ring Q1, W, m and n are each as defined in the description.