公开(公告)号：US20070167466A1

公开(公告)日：2007-07-19

申请号：US10555528

申请日：2004-05-06

申请人： Daniela Moravcova ,  Libor Havlicek ,  Vladimir Krystof ,  Rene Lenobel ,  Pavla Binarova ,  Petr Mlejnek ,  Borek Vojtesek ,  Stjepan Uldrijan ,  Thomas Schmulling ,  Miroslav Strnad

发明人： Daniela Moravcova ,  Libor Havlicek ,  Vladimir Krystof ,  Rene Lenobel ,  Pavla Binarova ,  Petr Mlejnek ,  Borek Vojtesek ,  Stjepan Uldrijan ,  Thomas Schmulling ,  Miroslav Strnad

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04

摘要： The invention relates to 3-,7-disubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I (I), and pharmaceutically acceptable salts thereof, wherein R3 is selected from the group consisting of alkyl, cycloalkyl, cycloalkyl alkyl, cycloheteroalkyl alkyl, cycloheteroalkyl, aryl, heterocycle, heteroaryl, arylalkyl, heteroarylalkyl, and heteroalkyl, wherein each of the groups may optionally be substituted, R7 is selected from the group consisting of halogen, hydroxyl, hydroxylamino, amino, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, unsubstituted or substituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted cycloheteroalkyl alkyl; R7′-X— wherein X is an —NH—, —N(alkyl)-, -0- or —S— moiety and R7′ is selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylcycloalkyl, arylalkyl, heterocycle, heterocyclealkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted arylalkyl, substituted heterocycle, substituted heteroaryl, substituted heteroarylalkyl, substituted heteroalkyl, substituted cycloalkyl alkyl and substituted cycloheteroalkyl alkyl, wherein the groups are preferably substituted by more than one halogen, hydroxyl, amino, mercapto, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, alkyl, alkoxy, and substituted alkyl group.

摘要翻译： 本发明涉及由通式I（I）表示的3-，7-二取代的吡唑并[4,3-d]嘧啶及其药学上可接受的盐，其中R 3选自烷基，环烷基，环烷基烷基 ，杂环烷基烷基，环杂烷基，芳基，杂环，杂芳基，芳基烷基，杂芳基烷基和杂烷基，其中每个基团可任选被取代，R 7选自卤素，羟基，羟基氨基，氨基，羧基，氰基，硝基 取代或未取代的芳烷基，取代或未取代的杂烷基，取代或未取代的杂芳基烷基，取代或未取代的环烷基烷基，取代或未取代的环杂烷基烷基;取代或未取代的芳基烷基， 其中X是-NH-，-N（烷基） - ， - O-或-S-部分，并且R 7'选自H，烷基，环烷基，芳基，烷基环烷基，芳基烷基， 杂环，杂环烷基，取代的烷基，取代的环烷基，取代的芳基，取代的芳基烷基，取代的杂环，取代的杂芳基，取代的杂芳基烷基，取代的杂烷基，取代的环烷基烷基和取代的环杂烷基烷基，其中基团优选被多于一个的卤素，羟基， 氨基，巯基，羧基，氰基，硝基，酰胺基，磺基，氨基磺酰氨基，氨基氨基，烷基，烷氧基和取代的烷基。