公开(公告)号：US11407757B2

公开(公告)日：2022-08-09

申请号：US16958721

申请日：2018-12-26

Applicant: Development Center for Biotechnology

Inventor： Shih-Chieh Yen ,  Chu-Bin Liao ,  Hui-Chen Wang ,  Po-Ting Chen ,  Yu-Chih Pan ,  Tsung-Hui Li ,  Bo-Rong Chen ,  Shian-Yi Chiou

IPC: C07D487/04 ,  A61P35/00

Abstract: Disclosed are compounds of formula (I) below and tautomers, stereoisomers, isotopologues, or pharmaceutically acceptable salts thereof: in which each of variables R1, ring A, L, W, V, and G is defined herein. Also disclosed are a method for treating disease or disorder mediated by Tyro3, Axl, and/or Mer kinase with a compound of formula (I) or a tautomer, stereoisomer, isotopologue, or salt thereof and a pharmaceutical composition containing same.