公开(公告)号：US20240197780A1

公开(公告)日：2024-06-20

申请号：US18542884

申请日：2023-12-18

Applicant: Development Center for Biotechnology

Inventor： Li-Shuang AI ,  Yu-Hsun LO ,  Cheng-Chou YU ,  Yi-Jiue TSAI ,  Hsin-Yi TSAI ,  Show-Shan SHEU ,  Yi-Tian HE ,  Pei-Yi TSAI ,  Chia-Tsen LAI

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K16/28

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464411 ,  A61K39/464429 ,  A61P35/00 ,  C07K14/70503 ,  C07K14/70596 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2239/15 ,  A61K2239/17 ,  A61K2239/21 ,  A61K2239/29

Abstract: Disclosed herein is a chimeric antigen receptor (CAR) comprising a single-chain variable fragment specific to Globo H, a hinge and transmembrane domain, a co-stimulatory molecule, and a cytoplasmic domain. According to some embodiments of the present disclosure, the CAR further comprises a single-chain variable fragment specific to PD-L1, and optionally, a fragment crystallizable region of an immunoglobulin. Also disclosed herein are isolated nucleic acids encoding the CAR pharmaceutical kits comprising the isolated immune cells expressing the CAR, and methods of treating cancers by using isolated immune cells.