专利检索 ap:("Dorre A. Grueneberg" OR "Ori Kalid" OR "Jun Xian" OR "Sharanappa B. Rajur" OR "Hwa-Ok Kim" OR "Venugopal Rao Neelagiri" OR "Paresh Salgaonkar" OR "Divakaramenon Sethumadhavan" OR "Chaeho Moon" OR "Madhavi Neelagiri") AND inv:"Chaeho Moon" 第 1 页

1.

发明授权
Methods, compounds, and compositions for inhibition of ROS 有权

公开(公告)号：US09963452B2

公开(公告)日：2018-05-08

申请号：US14775825

申请日：2014-03-13

申请人： Dorre A. Grueneberg , Ori Kalid , Jun Xian , Sharanappa B. Rajur , Hwa-Ok Kim , Venugopal Rao Neelagiri , Paresh Salgaonkar , Divakaramenon Sethumadhavan , Chaeho Moon , Madhavi Neelagiri

发明人： Dorre A. Grueneberg , Ori Kalid , Jun Xian , Sharanappa B. Rajur , Hwa-Ok Kim , Venugopal Rao Neelagiri , Paresh Salgaonkar , Divakaramenon Sethumadhavan , Chaeho Moon , Madhavi Neelagiri

IPC分类号： A61K31/505 , A61K31/53 , C07D487/04 , A61K45/06 , A61K31/404 , A61K31/4375 , A61K31/454 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/551 , C07D209/08 , C07D243/14 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/194 , A61K31/437 , A61K31/452 , A61K31/4545

CPC分类号： C07D487/04 , A61K31/194 , A61K31/404 , A61K31/437 , A61K31/4375 , A61K31/452 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/551 , A61K45/06 , C07D209/08 , C07D243/14 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K2300/00

摘要： The present invention relates to a method using some novel compounds and compositions for the inhibition of ROS tyrosine kinase. In particular, the present invention covers a method to treat abnormal cell growth, such as cancer, with ROS 10 inhibitors and compositions having ROS inhibitors. An illustrative compound of the invention is shown below Formula (I).