公开(公告)号：US20230310333A1

公开(公告)日：2023-10-05

申请号：US18043594

申请日：2021-08-23

Applicant: East China University of Science and Technology

Inventor： Weiping ZHU ,  Yun FU ,  Yufang XU ,  Xuhong QIAN

IPC: A61K9/51 ,  A61K38/28

CPC classification number: A61K9/5115 ,  A61K38/28 ,  A61K9/0021

Abstract: A mesoporous silica nanoparticle controlled release system, a preparation method thereof and an application thereof, and specifically provides a mesoporous silica nanomaterial that can be used for controlled release is disclosed. The mesoporous silica nanomaterial that can be used for controlled release comprises a mesoporous silica nanoparticle functionalized by means of a polyhydroxy compound and a nanoparticle plugging agent functionalized by means of a phenylboronic acid compound. When substrate concentration is relatively low, the nanomaterial achieves “zero early release”; when substrate concentration is relatively high, mesoporous pores blocked by the plugging agent are opened and active ingredients are released. The nanomaterial can be loaded into microneedles and microneedle array patches used to treat diabetes or to control blood sugar levels in patients.